Assignment of absolute configuration of cyclic secondary amines by NMR techniques using Mosher's method: a general procedure exemplified with (-)-isoanabasine
文献类型：期刊论文
| 作者 | Kang CQ ; Guo HQ ; Qiu XP ; Bai XL ; Yao HB ; Gao LX |
| 刊名 | magnetic resonance in chemistry
 |
| 出版日期 | 2006 |
| 卷号 | 44期号:1页码:20-24 |
| 关键词 | CARBOXYLATE-CATALYZED DECOMPOSITION REDUCTIVE AMINATION-CYCLIZATION ENANTIOSELECTIVE SYNTHESIS ASYMMETRIC-SYNTHESIS EFFICIENT SYNTHESIS ACID COMPLEXATION DERIVATIVES ALCOHOLS REAGENT |
| ISSN号 | 0749-1581 |
| 通讯作者 | gao lx |
| 中文摘要 | a general procedure to determine the absolute configuration of cyclic secondary amines with mosher's nmr method is demonstrated, with assignment of absolute configuration of isoanabasine as an example. each mosher amide can adopt two stable conformations (named rotamers) caused by hindered rotation around amide c-n bond. via a three-step structural analysis of four rotamers, the absolute configuration of (-)-isoanabasine is deduced to be (r) on the basis of newman projections, which makes it easy to understand and clarify the application of mosher's method to cyclic secondary amines. furthermore, it was observed that there was an unexpected ratio of rotamers of mosher amide derived from (r)-isoanabasine and (r)-mosher acid. this phenomenon implied that it is necessary to distinguish the predominant rotamer from the minor one prior to determining the absolute configuration while using this technique. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000234603900004 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16513]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kang CQ,Guo HQ,Qiu XP,et al. Assignment of absolute configuration of cyclic secondary amines by NMR techniques using Mosher's method: a general procedure exemplified with (-)-isoanabasine[J]. magnetic resonance in chemistry,2006,44(1):20-24. |
| APA | Kang CQ,Guo HQ,Qiu XP,Bai XL,Yao HB,&Gao LX.(2006).Assignment of absolute configuration of cyclic secondary amines by NMR techniques using Mosher's method: a general procedure exemplified with (-)-isoanabasine.magnetic resonance in chemistry,44(1),20-24. |
| MLA | Kang CQ,et al."Assignment of absolute configuration of cyclic secondary amines by NMR techniques using Mosher's method: a general procedure exemplified with (-)-isoanabasine".magnetic resonance in chemistry 44.1(2006):20-24. |
入库方式： OAI收割
来源：长春应用化学研究所
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