Diluting thiol-derivatized oligonucleotide monolayers on Au(111) by mercaptohexanol replacement reaction
文献类型：期刊论文
| 作者 | Song YH ; Liu YQ ; Yang ML ; Zhang BL ; Li Z |
| 刊名 | applied surface science
 |
| 出版日期 | 2006 |
| 卷号 | 252期号:16页码:5693-5699 |
| 关键词 | SELF-ASSEMBLED MONOLAYERS ATOMIC-FORCE MICROSCOPY SCANNING-TUNNELING-MICROSCOPY DNA HYBRIDIZATION GOLD SURFACES NUCLEIC-ACID PHASE-SEPARATION PROBE ELECTRODE MICROELECTRODES |
| ISSN号 | 0169-4332 |
| 通讯作者 | li z |
| 中文摘要 | surface replacement reaction of thiol-derivatized, single-stranded oligonucleotide (hs-ssdna) by mercaptohexanol (mch) is investigated in order to reduce surface density of the hs-ssdna adsorbed to au(111) surface. cyclic voltammograms (cvs) and scanning tunneling microscopy (stm) are employed to assess the composition and state of these mixed monolayers. it is found that each cv of mixed self-assembled monolayers (sams) only shows a single reductive desorption peak, which suggests that the resulted, mixed sams do not form discernable phase-separated domains. the peak potential gradually shifts to negative direction and the peak area increases step by step over the whole replacement process. by analyzing these peak areas, it is concluded that two mch molecules will replace one hs-ssdna molecule and relative coverage can also be estimated as a function of exposing time. the possible mechanism of the replacement reaction is also proposed. the dna surface density exponentially reduces with the exposing time increasing, in other words, the replacement reaction is very fast in the first several hours and then gradually slows down. moreover, the morphological change in the process is also followed by stm. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238623500008 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16629]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Song YH,Liu YQ,Yang ML,et al. Diluting thiol-derivatized oligonucleotide monolayers on Au(111) by mercaptohexanol replacement reaction[J]. applied surface science,2006,252(16):5693-5699. |
| APA | Song YH,Liu YQ,Yang ML,Zhang BL,&Li Z.(2006).Diluting thiol-derivatized oligonucleotide monolayers on Au(111) by mercaptohexanol replacement reaction.applied surface science,252(16),5693-5699. |
| MLA | Song YH,et al."Diluting thiol-derivatized oligonucleotide monolayers on Au(111) by mercaptohexanol replacement reaction".applied surface science 252.16(2006):5693-5699. |
入库方式： OAI收割
来源：长春应用化学研究所
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