Synthesis and kinetics of a novel mimic with glutathione peroxidase activity - Tellurium-containing hyaluronic acid (TeHA)
文献类型：期刊论文
| 作者 | Chen ZB ; Zhang BX ; Huang ZX ; Peng QL ; Chen J ; Wang Y ; Zhang JG ; Jiang GZ ; Li WS ; Liu LY |
| 刊名 | chinese chemical letters
 |
| 出版日期 | 2006 |
| 卷号 | 17期号:7页码:969-972 |
| ISSN号 | 1001-8417 |
| 通讯作者 | liu ly |
| 中文摘要 | a novel mimic was synthesized by modifying hyaluronic acid (ha) with tellurium, whose function is similar to that of glutathione peroxidase (gpx). the structure of teha was characterized by means of ir and nmr, the target-te was located at -ch2oh of the n-acetyl-d-glucosamine of ha. the h2o2 reducing activity of teha, by glutathione (gsh), was 163.6 u/mu mol according to wilson's method. in contrast to other mimics, teha displayed the highest activity. moreover, teha accepted many hydroperoxides as its substrates, such as h2o2, cumenyl hydroperoxide (cuooh) and tert-butyl hydroperoxide (t-buooh), and cuooh was the optimal substrate of teha. a ping-pong mechanism was observed in the steady-state kinetic studies of the reactions catalyzed by teha. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239982000033 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16965]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen ZB,Zhang BX,Huang ZX,et al. Synthesis and kinetics of a novel mimic with glutathione peroxidase activity - Tellurium-containing hyaluronic acid (TeHA)[J]. chinese chemical letters,2006,17(7):969-972. |
| APA | Chen ZB.,Zhang BX.,Huang ZX.,Peng QL.,Chen J.,...&Liu LY.(2006).Synthesis and kinetics of a novel mimic with glutathione peroxidase activity - Tellurium-containing hyaluronic acid (TeHA).chinese chemical letters,17(7),969-972. |
| MLA | Chen ZB,et al."Synthesis and kinetics of a novel mimic with glutathione peroxidase activity - Tellurium-containing hyaluronic acid (TeHA)".chinese chemical letters 17.7(2006):969-972. |
入库方式： OAI收割
来源：长春应用化学研究所
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