Investigation on acute biochemical effects of Ce(NO3)(3) on liver and kidney tissues by MAS H-1 NMR spectroscopic-based metabonontic approach
文献类型：期刊论文
| 作者 | Wu HF ; Zhang XY ; Li XJ ; Li ZF ; Liao PQ ; Li WS ; Wu YJ ; Pei FK |
| 刊名 | journal of rare earths
 |
| 出版日期 | 2006 |
| 卷号 | 24期号:3页码:357-363 |
| ISSN号 | 1002-0721 |
| 关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY VOLE CLETHRIONOMYS-GLAREOLUS PATTERN-RECOGNITION METHODS ALPHA-NAPHTHYLISOTHIOCYANATE NMR-SPECTROSCOPY URINE RAT H-1 CLASSIFICATION LA(NO3)(3) |
| 通讯作者 | pei fk |
| 中文摘要 | high resolution magic angle spinning (mas)-h-1 nuclear magnetic resonance (nmr) spectroscopic-based metabonomic approach was applied to the investigation on the acute biochemical effects of ce(no-3)(3). male wistar rats were administrated with various doses of ce (no3)(3)(2, 10, and 50 mg(.)kg(-1) body weight), and mas h-1 nmr spectra of intact liver and kidney tissues were analyzed using principal component analysis to extract toxicity information. the biochemical effects of ce (no3)(3) were characterized by the increase of triglycerides and lactate and the decrease of glycogen in rat liver tissue, together with an elevation of the triglyceride level and a depletion of glycerophosphocholine and betaine in kidney tissues. the target lesions of ce (no3)(3) on liver and kidney were found by mas nmr-based metabonomic method. this study demonstrates that the combination of mas h-1 nmr and pattern recognition analysis can be an effective method for studies of biochemical effects of rare earths. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239079000020 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16969]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu HF,Zhang XY,Li XJ,et al. Investigation on acute biochemical effects of Ce(NO3)(3) on liver and kidney tissues by MAS H-1 NMR spectroscopic-based metabonontic approach[J]. journal of rare earths,2006,24(3):357-363. |
| APA | Wu HF.,Zhang XY.,Li XJ.,Li ZF.,Liao PQ.,...&Pei FK.(2006).Investigation on acute biochemical effects of Ce(NO3)(3) on liver and kidney tissues by MAS H-1 NMR spectroscopic-based metabonontic approach.journal of rare earths,24(3),357-363. |
| MLA | Wu HF,et al."Investigation on acute biochemical effects of Ce(NO3)(3) on liver and kidney tissues by MAS H-1 NMR spectroscopic-based metabonontic approach".journal of rare earths 24.3(2006):357-363. |
入库方式： OAI收割
来源：长春应用化学研究所
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