Study of ionizable drugs transfer across the water/1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system
文献类型：期刊论文
| 作者 | Zhang MQ ; Sun P ; Chen Y ; Li F ; Gao Z ; Shao YH |
| 刊名 | chinese science bulletin
 |
| 出版日期 | 2003 |
| 卷号 | 48期号:12页码:1234-1239 |
| ISSN号 | 1001-6538 |
| 关键词 | IONIC PARTITION DIAGRAMS LIQUID-LIQUID INTERFACE 1 VOLTAMMETRY TIP 2-DICHLOROETHANE INTERFACE |
| 通讯作者 | shao yh |
| 中文摘要 | the electrochemical behavior of ionizable drugs (amitriptyline, diphenhydramine and trihexyphenedyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = v-o/v-w) equal to 1 are investigated by cyclic voltammetry. the system is composed of an aqueous droplet supported at an ag/agcl disk electrode and it was covered with an organic solution. in this manner, a conventional three-electrode potentiostat can be used to study the ionizable drugs transfer process at a liquid/liquid interface. physicochemical parameters such as the formal transfer potential, the gibbs energy of transfer and the standard partition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. the obtained results have been summarized in ionic partition diagrams, which are a useful tool for predicting and interpreting the transfer mechanisms of ionizable drugs at the liquid/liquid interfaces and biological membranes. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000184249300017 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17389]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang MQ,Sun P,Chen Y,et al. Study of ionizable drugs transfer across the water/1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system[J]. chinese science bulletin,2003,48(12):1234-1239. |
| APA | Zhang MQ,Sun P,Chen Y,Li F,Gao Z,&Shao YH.(2003).Study of ionizable drugs transfer across the water/1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system.chinese science bulletin,48(12),1234-1239. |
| MLA | Zhang MQ,et al."Study of ionizable drugs transfer across the water/1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system".chinese science bulletin 48.12(2003):1234-1239. |
入库方式： OAI收割
来源：长春应用化学研究所
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