Simultaneous determination of tramadol and lidocaine in urine by end-column capillary electrophoresis with electrochemiluminescence detection
文献类型：期刊论文
| 作者 | Cao WD ; Liu JF ; Qiu HB ; Yang XR ; Wang EK |
| 刊名 | electroanalysis
 |
| 出版日期 | 2002 |
| 卷号 | 14期号:22页码:1571-1576 |
| 关键词 | RU(BPY)(3)(3+)-BASED CHEMILUMINESCENCE DETECTION PERFORMANCE LIQUID-CHROMATOGRAPHY SOLID-PHASE MICROEXTRACTION ZONE-ELECTROPHORESIS ELECTROGENERATED CHEMILUMINESCENCE ELECTROCHEMICAL DETECTION GAS-CHROMATOGRAPHY MASS-SPECTROMETRY LOCAL-ANESTHETICS HUMAN PLASMA |
| ISSN号 | 1040-0397 |
| 通讯作者 | wang ek |
| 中文摘要 | tramadol and lidocaine, used as analgesic and local anesthetic in surgery, are partly excreted by kidney. for the first time, we developed a simple and sensitive method, based on capillary electrophoresis with electrochemiluminescence (ecl) detection by end column mode without joint to monitor tramadol and lidocaine in urine. to eliminate the influence of ionic strength of urine sample, analytes were extracted by ether. tripropylamine (tpa) was used as internal standard. ne recoveries of tramadol and lidocaine were between 94% and 97% at different levels. the method exhibited the linear range for the tramadol and lidocaine from 1.0 x 10(-7) to 1.0 x 10(-4) mol/l with correlation efficient of 0.998. the relative standard deviation (rsd) was 2.9% and 2.7% (n = 8) for tramadol and lidocaine, respectively. the limit of detection (lod) was 6.0 x 10(-8) mol/l and 4.5 x 10(-8), mol/l (s/n = 3) for tramadol and lidocaine, respectively. the application for detecting tramadol and lidocaine in urine of patients showed that the method was valuable in clinical and biochemical laboratories for detecting tramadol, lidocaine and other tertiary amine pharmaceuticals for various purpose, such as metabolism investigation. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000179907200006 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17499]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cao WD,Liu JF,Qiu HB,et al. Simultaneous determination of tramadol and lidocaine in urine by end-column capillary electrophoresis with electrochemiluminescence detection[J]. electroanalysis,2002,14(22):1571-1576. |
| APA | Cao WD,Liu JF,Qiu HB,Yang XR,&Wang EK.(2002).Simultaneous determination of tramadol and lidocaine in urine by end-column capillary electrophoresis with electrochemiluminescence detection.electroanalysis,14(22),1571-1576. |
| MLA | Cao WD,et al."Simultaneous determination of tramadol and lidocaine in urine by end-column capillary electrophoresis with electrochemiluminescence detection".electroanalysis 14.22(2002):1571-1576. |
入库方式： OAI收割
来源：长春应用化学研究所
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