Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI
文献类型：期刊论文
| 作者 | Sun GY ; Feng JH ; Jing FY ; Pei FK ; Liu ML |
| 刊名 | journal of magnetism and magnetic materials
 |
| 出版日期 | 2003 |
| 卷号 | 265期号:2页码:123-129 |
| 关键词 | MAGNETIC-RESONANCE SERUM-ALBUMIN GADOLINIUM(III) RELAXATION DEXTRAN BIODISTRIBUTION DERIVATIVES MODEL ACID |
| ISSN号 | 0304-8853 |
| 通讯作者 | pei fk |
| 中文摘要 | macromolecular conjugates of two kinds of natural polysaccharides, that from panax quinquefolium linn (pqps) and ganoderma applanatum pat (gaps), with gadolinium-diethylenetriaminepenta-acetic acid (gd-dtpa) have been synthesized and characterized by means of ftir, elementary analysis and icp-aes. their stability was investigated by competition study with ca2+, edta (ethylenediaminetetraacetic acid) and dtpa. polysaccharide-bound complexes exhibit t-1 relaxivities of 1.5-1.7 times that of gd-dtpa in d2o at 25degreesc and 9.4t. mr imaging of sprague-dawley (sd) rats showed remarkable enhancement in rat liver and kidney after i.v. injection of these two complexes: liver parenchyma 60.9+/-5.6%, 57.8+/-7.4% at 65-85 min; kidney 144.9+/-14.5%, 199.9+/-25.4% at 10-30 min for pqps-gddtpa, gaps-gd-dtpa at gadolinium dose of 0.083 and 0.082 mmol/kg, respectively. our preliminary in vivo and in vitro study indicates that the two kinds of polysaccharide-bound complexes are potential tissue-specific contrast agents for mri. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000185120100004 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17573]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun GY,Feng JH,Jing FY,et al. Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI[J]. journal of magnetism and magnetic materials,2003,265(2):123-129. |
| APA | Sun GY,Feng JH,Jing FY,Pei FK,&Liu ML.(2003).Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI.journal of magnetism and magnetic materials,265(2),123-129. |
| MLA | Sun GY,et al."Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI".journal of magnetism and magnetic materials 265.2(2003):123-129. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。