Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents
文献类型：期刊论文
| 作者 | Feng JH ; Sun GY ; Pei FK ; Liu ML |
| 刊名 | bioorganic & medicinal chemistry
 |
| 出版日期 | 2003 |
| 卷号 | 11期号:15页码:3359-3366 |
| 关键词 | DIETHYLENETRIAMINEPENTAACETIC ACID BIS(METHYLAMIDE) SERUM-ALBUMIN SOLUTION BLOOD-POOL AGENT MAGNETIC-RESONANCE LANTHANIDE(III) COMPLEXES GADOLINIUM(III) COMPLEXES RELAXATION DYNAMICS LIGAND GDDTPA |
| ISSN号 | 0968-0896 |
| 通讯作者 | pei fk |
| 中文摘要 | four neutral gadolinium complexes of diethylenetriaminepentaacetic acid (dtpa)-bisamide derivatives have been synthesized and characterized. their potential application as tissue-specific and low-osmolarity mri contrast agents has been evaluated by in vitro and in vivo experiments. their measured relaxivities in d2o, bovine serum albumin and human serum transferrin solutions showed favorable relaxation ability. in vivo studies have proven that gd(dtpa-bdma), gd(dtpa-bin), and gd(cyclic-dtpa-1,2-pn) could be promising liver-specific mri contrast agents and gd(dtpa-bdma), and gd(cyclic-dtpa-1,2-pn) have favorable renal excretion capability. among them, gd(cyclic-dtpa-1,2-pn) is a more powerful hepatic contrast agent and gd(dtpa-bin) provides the stable imaging contrast for several hours. they also show a lower toxicity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000183935400015 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17577]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng JH,Sun GY,Pei FK,et al. Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents[J]. bioorganic & medicinal chemistry,2003,11(15):3359-3366. |
| APA | Feng JH,Sun GY,Pei FK,&Liu ML.(2003).Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents.bioorganic & medicinal chemistry,11(15),3359-3366. |
| MLA | Feng JH,et al."Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents".bioorganic & medicinal chemistry 11.15(2003):3359-3366. |
入库方式： OAI收割
来源：长春应用化学研究所
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