Evaluation of bioeffects of a long-term administering ChangLe on rat by proton NMR method and biochemical examination
文献类型：期刊论文
| 作者 | Feng JH ; Li XJ ; Pei FK ; Niu YX |
| 刊名 | chinese journal of chemistry
 |
| 出版日期 | 2003 |
| 卷号 | 21期号:3页码:320-326 |
| 关键词 | NUCLEAR-MAGNETIC-RESONANCE H-1-NMR SPECTROSCOPY RENAL-FAILURE BLOOD-PLASMA URINE METABOLISM PATTERN SERUM |
| ISSN号 | 1001-624x |
| 通讯作者 | pei fk |
| 中文摘要 | high resolution h-1 nuclear magnetic resonance ( nmr) spectroscopy has been employed to assess long-term toxicological effects of changle (a kind of rare earth complex applied in agriculture). male wistar rats were administrated orally with changle at doses of 0, 0.1, 0.2, 2.0, 10 and 20 mg/kg body weight daily, respectively, for 6 months. urine was collected at-day 30, 60, go and serum samples were taken after 6 months. many low-molecular weight metabolites were identified by h-1 nmr spectra of rat urine. a decrease in citrate and an increase in ketone bodies, creatinine, dma, dmg, tmao, and taurine in the urine of the rats. receiving high doses were found by h-1 nmr spectra. these may mean that high-dosage of changle impairs the specific region of liver and kidney, such as renal tubule and mitochondria. the decrease in citrate and the increase in succinate and alpha-ketoglutarate were attributed to a combination of the inhibition of certain citric acid enzymes, renal tubular acidosis and the abnormal fatty acid catabolism. the information of the renal capillary necrosis could be derived from the increase in dmia, dmg and tmao. the increase in taurine was due to hepatic mitochondria dysfunction. the conclusions were supported by the results of biochemical measure. merits and enzymatic assay. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000182380800019 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17581]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng JH,Li XJ,Pei FK,et al. Evaluation of bioeffects of a long-term administering ChangLe on rat by proton NMR method and biochemical examination[J]. chinese journal of chemistry,2003,21(3):320-326. |
| APA | Feng JH,Li XJ,Pei FK,&Niu YX.(2003).Evaluation of bioeffects of a long-term administering ChangLe on rat by proton NMR method and biochemical examination.chinese journal of chemistry,21(3),320-326. |
| MLA | Feng JH,et al."Evaluation of bioeffects of a long-term administering ChangLe on rat by proton NMR method and biochemical examination".chinese journal of chemistry 21.3(2003):320-326. |
入库方式： OAI收割
来源：长春应用化学研究所
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