Triplex selective 2-(2-naphthyl)quinoline compounds: Origins of affinity and new design principles
文献类型：期刊论文
| 作者 | Chaires JB ; Ren JS ; Henary M ; Zegrocka O ; Bishop GR ; Strekowski L |
| 刊名 | journal of the american chemical society
 |
| 出版日期 | 2003 |
| 卷号 | 125期号:24页码:7272-7283 |
| 关键词 | HELIX SPECIFIC INTERCALATORS FORMING OLIGONUCLEOTIDES TRIFLUOROMETHYL GROUP ANTI-HIV-1 AGENTS ETHIDIUM-BROMIDE GENE-EXPRESSION BINDING LIGANDS DNA TRIPLEXES NUCLEIC-ACIDS SEQUENCE |
| ISSN号 | 0002-7863 |
| 通讯作者 | chaires jb |
| 中文摘要 | a novel competition dialysis assay was used to investigate the structural selectivity of a series of substituted 2-(2-naphthyl)quinoline compounds designed to target triplex dna. the interaction of 14 compounds with 13 different nucleic acid sequences and structures was studied. a striking selectivity for the triplex structure poly da:[poly dt](2) was found for the majority of compounds studied. quantitative analysis of the competition dialysis binding data using newly developed metrics revealed that these compounds are among the most selective triplex-binding agents synthesized to date. a quantitative structure-affinity relationship (qsar) was derived using triplex binding data for all 14 compounds used in these studies. the qsar revealed that the primary favorable determinant of triplex binding free energy is the solvent accessible surface area. triplex binding affinity is negatively correlated with compound electron affinity and the number of hydrogen bond donors. the qsar provides guidelines for the design of improved triplex-binding agents. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000183503500036 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17813]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chaires JB,Ren JS,Henary M,et al. Triplex selective 2-(2-naphthyl)quinoline compounds: Origins of affinity and new design principles[J]. journal of the american chemical society,2003,125(24):7272-7283. |
| APA | Chaires JB,Ren JS,Henary M,Zegrocka O,Bishop GR,&Strekowski L.(2003).Triplex selective 2-(2-naphthyl)quinoline compounds: Origins of affinity and new design principles.journal of the american chemical society,125(24),7272-7283. |
| MLA | Chaires JB,et al."Triplex selective 2-(2-naphthyl)quinoline compounds: Origins of affinity and new design principles".journal of the american chemical society 125.24(2003):7272-7283. |
入库方式： OAI收割
来源：长春应用化学研究所
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