Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Guo MQ ; Zhang SQ ; Song FR ; Wang DW ; Liu ZQ ; Liu SY |
| 刊名 | journal of mass spectrometry
 |
| 出版日期 | 2003 |
| 卷号 | 38期号:7页码:723-731 |
| 关键词 | FAST-ATOM-BOMBARDMENT BETA-CYCLODEXTRIN INCLUSION COMPLEXES IONSPRAY |
| ISSN号 | 1076-5174 |
| 通讯作者 | liu sy |
| 中文摘要 | non-covalent inclusion complexes formed between an anti-inflammatory drug, oleanolic acid (oa), and alpha-, beta- and gamma-cyclodextrins (cds) were investigated by means of solubility studies and electrospray ionization tandem mass spectrometry (esi-msn). the order of calculated association constants (k-1:1) of complexes between oa and different cds in solution is in good agreement with the order of their relative peak intensities and the relative cid energies of the complexes under the same esi-msn conditions. these results indicate a direct correlation between the behaviors of solution- and gas-phase complexes. esi-ms can thus be used to evaluate solution-phase non-covalent complexes successfully. the experimental results show that the most stable 1:1 inclusion complexes between three cds and oa can be formed, but 2:1 cd-oa complexes can be formed with beta- and gamma-cds. multi-component complexes of alpha-cd-oa-beta-cd (1:1:1), alpha-cd-oa-gamma-cd (1:1:1) and beta-cd-oa-gamma-cd (1:1:1) were found in equimolar cd mixtures with excess oa. the formation of 2:1 and multi-component 1:1:1 non-covalent cd-oa complexes indicates that beta- and gamma-cd are able to form sandwich-type inclusion non-covalent complexes with oa. the above results can be partly supported by the relative sizes of oa and cd cavities by molecular modeling calculations. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000184457300004 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17851]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guo MQ,Zhang SQ,Song FR,et al. Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry[J]. journal of mass spectrometry,2003,38(7):723-731. |
| APA | Guo MQ,Zhang SQ,Song FR,Wang DW,Liu ZQ,&Liu SY.(2003).Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry.journal of mass spectrometry,38(7),723-731. |
| MLA | Guo MQ,et al."Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry".journal of mass spectrometry 38.7(2003):723-731. |
入库方式： OAI收割
来源：长春应用化学研究所
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