中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry

文献类型:期刊论文

作者Guo MQ ; Zhang SQ ; Song FR ; Wang DW ; Liu ZQ ; Liu SY
刊名journal of mass spectrometry
出版日期2003
卷号38期号:7页码:723-731
关键词FAST-ATOM-BOMBARDMENT BETA-CYCLODEXTRIN INCLUSION COMPLEXES IONSPRAY
ISSN号1076-5174
通讯作者liu sy
中文摘要non-covalent inclusion complexes formed between an anti-inflammatory drug, oleanolic acid (oa), and alpha-, beta- and gamma-cyclodextrins (cds) were investigated by means of solubility studies and electrospray ionization tandem mass spectrometry (esi-msn). the order of calculated association constants (k-1:1) of complexes between oa and different cds in solution is in good agreement with the order of their relative peak intensities and the relative cid energies of the complexes under the same esi-msn conditions. these results indicate a direct correlation between the behaviors of solution- and gas-phase complexes. esi-ms can thus be used to evaluate solution-phase non-covalent complexes successfully. the experimental results show that the most stable 1:1 inclusion complexes between three cds and oa can be formed, but 2:1 cd-oa complexes can be formed with beta- and gamma-cds. multi-component complexes of alpha-cd-oa-beta-cd (1:1:1), alpha-cd-oa-gamma-cd (1:1:1) and beta-cd-oa-gamma-cd (1:1:1) were found in equimolar cd mixtures with excess oa. the formation of 2:1 and multi-component 1:1:1 non-covalent cd-oa complexes indicates that beta- and gamma-cd are able to form sandwich-type inclusion non-covalent complexes with oa. the above results can be partly supported by the relative sizes of oa and cd cavities by molecular modeling calculations.
收录类别SCI收录期刊论文
语种英语
WOS记录号WOS:000184457300004
公开日期2010-09-13
源URL[http://202.98.16.49/handle/322003/17851]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Guo MQ,Zhang SQ,Song FR,et al. Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry[J]. journal of mass spectrometry,2003,38(7):723-731.
APA Guo MQ,Zhang SQ,Song FR,Wang DW,Liu ZQ,&Liu SY.(2003).Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry.journal of mass spectrometry,38(7),723-731.
MLA Guo MQ,et al."Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry".journal of mass spectrometry 38.7(2003):723-731.

入库方式: OAI收割

来源:长春应用化学研究所

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