First-passage time distribution and non-Markovian diffusion dynamics of protein folding
文献类型：期刊论文
| 作者 | Lee CL ; Stell G ; Wang J |
| 刊名 | journal of chemical physics
 |
| 出版日期 | 2003 |
| 卷号 | 118期号:2页码:959-968 |
| 关键词 | RANDOM-ENERGY-MODEL CHYMOTRYPSIN INHIBITOR-2 FLUCTUATING ENVIRONMENTS SINGLE MOLECULES LANDSCAPE MODEL KINETICS HETEROPOLYMERS PATHWAYS INTERMITTENCY MECHANISM |
| ISSN号 | 0021-9606 |
| 通讯作者 | stell g |
| 中文摘要 | we study the kinetics of protein folding via statistical energy landscape theory. we concentrate on the local-connectivity case, where the configurational changes can only occur among neighboring states, with the folding progress described in terms of an order parameter given by the fraction of native conformations. the non-markovian diffusion dynamics is analyzed in detail and an expression for the mean first-passage time (mfpt) from non-native unfolded states to native folded state is obtained. it was found that the mfpt has a v-shaped dependence on the temperature. we also find that the mfpt is shortened as one increases the gap between the energy of the native and average non-native folded states relative to the fluctuations of the energy landscape. the second- and higher-order moments are studied to infer the first-passage time distribution. at high temperature, the distribution becomes close to a poisson distribution, while at low temperatures the distribution becomes a levy-type distribution with power-law tails, indicating a nonself-averaging intermittent behavior of folding dynamics. we note the likely relevance of this result to single-molecule dynamics experiments, where a power law (levy) distribution of the relaxation time of the underlined protein energy landscape is observed. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000179949700049 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://202.98.16.49/handle/322003/17933]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lee CL,Stell G,Wang J. First-passage time distribution and non-Markovian diffusion dynamics of protein folding[J]. journal of chemical physics,2003,118(2):959-968. |
| APA | Lee CL,Stell G,&Wang J.(2003).First-passage time distribution and non-Markovian diffusion dynamics of protein folding.journal of chemical physics,118(2),959-968. |
| MLA | Lee CL,et al."First-passage time distribution and non-Markovian diffusion dynamics of protein folding".journal of chemical physics 118.2(2003):959-968. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。