Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy
文献类型：期刊论文
| 作者 | Huang WM ; Zhang ZL ; Hang XJ ; Tang JL ; Wang JG ; Dong SJ ; Wang EK |
| 刊名 | biophysical journal
 |
| 出版日期 | 2002 |
| 卷号 | 83期号:6页码:3245-3255 |
| 关键词 | POLYENE MACROLIDE ANTIBIOTICS AGGREGATION STATE DIPALMITOYLPHOSPHATIDYLCHOLINE BILAYERS PHOSPHOLIPID-BILAYERS SELF-ASSOCIATION LIPID MEMBRANES TOXICITY VESICLES MONOLAYERS DEPENDENCE |
| ISSN号 | 0006-3495 |
| 通讯作者 | wang ek |
| 中文摘要 | amphotericin b (amb) is a popular drug frequently applied in the treatment of systemic fungal infections. in the presence of ruthenium (ii) as the maker ion, the behavior of amb to form ion channels in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes were studied by cyclic votammetry, ac impedance spectroscopy, and uv/visible absorbance spectroscopy. different concentrations of amb ranging from a molecularly dispersed to a highly aggregated state of the drug were investigated. in a fixed cholesterol or ergosterol content (5 mol %) in glassy carbon electrode-supported model membranes, our results showed that no matter what form of amb, monomeric or aggregated, amb could form ion channels in supported ergosterol-containing phosphatidylcholine bilayer model membranes. however, amb could not form ion channels in its monomeric form in sterol-free and cholesterol-containing supported model membranes. on the one hand, when amb is present as an aggregated state, it can form ion channels in cholesterol-containing supported model membranes; on the other hand, only when amb is present as a relatively highly aggregated state can it form ion channels in sterol-free supported phosphatidylcholine bilayer model membranes. the results showed that the state of amb played an important role in forming ion channels in sterol-free and cholesterol-containing supported phosphatidylcholine bilayer model membranes. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000180256300029 |
| 公开日期 | 2010-11-03 |
| 源URL | [http://202.98.16.49/handle/322003/18131]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Huang WM,Zhang ZL,Hang XJ,et al. Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy[J]. biophysical journal,2002,83(6):3245-3255. |
| APA | Huang WM.,Zhang ZL.,Hang XJ.,Tang JL.,Wang JG.,...&Wang EK.(2002).Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy.biophysical journal,83(6),3245-3255. |
| MLA | Huang WM,et al."Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy".biophysical journal 83.6(2002):3245-3255. |
入库方式： OAI收割
来源：长春应用化学研究所
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