Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents
文献类型：期刊论文
| 作者 | Feng JH ; Sun GY ; Pei FK ; Liu ML |
| 刊名 | journal of inorganic biochemistry
 |
| 出版日期 | 2002 |
| 卷号 | 92期号:3-4页码:193-199 |
| 关键词 | HETEROPOLY COMPLEXES PROTON RELAXATION SERUM-ALBUMIN GLIOMA MODEL WATER STABILITY DEXTRAN |
| ISSN号 | 0162-0134 |
| 通讯作者 | pei fk |
| 中文摘要 | two gadolinium polyoxometalates, gd2p2w18o62 and k-15[(gdo)(3)(pw9o34)(2)], have been evaluated by in vivo as well as in vitro experiments as the candidates of tissue-specific magnetic resonance imaging (mri) contrast agents. t-1-relaxivities of 28.4 mm(-1)-s(-1) for gd2p2w18o62 and 11.2 mm(-1)-s(-1) for k-15[(gdo)(3)(pw9o34)(2)] (400 mhz, 25 degreesc) were higher than that of the commercial mri contrast agent (gddtpa). their relaxivities in bovine serum albumin and human serum transferrin were also reported. the favorable liver-specific contrast enhancement and renal excretion capability in in vivo mri with sprague-dawley rats after i.v. administration of k-15[(gdo)(3)(pw9o34)(2)] was demonstrated. in vivo and in vitro assay showed that k-15[(gdo)(3)(pw9o34)(2)] is a promising liver-specific mri contrast agent. however, gd2p2w18o62 did not show the favorable quality in vivo as expected from its high relaxivity in vitro, which was attributed to low bioavailability, indicating that it is of limited value as tissue-specific mri contrast agent. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000179620600008 |
| 公开日期 | 2010-11-03 |
| 源URL | [http://202.98.16.49/handle/322003/18177]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng JH,Sun GY,Pei FK,et al. Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents[J]. journal of inorganic biochemistry,2002,92(3-4):193-199. |
| APA | Feng JH,Sun GY,Pei FK,&Liu ML.(2002).Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents.journal of inorganic biochemistry,92(3-4),193-199. |
| MLA | Feng JH,et al."Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents".journal of inorganic biochemistry 92.3-4(2002):193-199. |
入库方式： OAI收割
来源：长春应用化学研究所
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