Interaction of low-molecular-weight chitosan with mimic membrane studied by electrochemical methods and surface plasmon resonance
文献类型：期刊论文
| 作者 | Yang F ; Cui XQ ; Yang XR |
| 刊名 | biophysical chemistry
 |
| 出版日期 | 2002 |
| 卷号 | 99期号:1页码:99-106 |
| 关键词 | SELF-ASSEMBLED MONOLAYERS EPITHELIAL-CELLS CACO-2 POORLY ABSORBABLE DRUGS ABSORPTION ENHANCERS TRANSFECTION EFFICIENCY DNA NANOPARTICLES SUPPORTED BILAYER GENE DELIVERY PERMEABILITY IMPEDANCE |
| ISSN号 | 0301-4622 |
| 通讯作者 | yang xr |
| 中文摘要 | chitosan has shown its potential as a non-viral gene carrier and an adsorption enhancer for subsequent drug delivery to cells. these results showed that chitosan acted as a membrane perturbant. however, there is currently a lack of direct experimental evidence of this membrane perturbance effect, especially for chitosans with low molecular weight (lmw). in this report, the interaction between a lipid (didodecyl dimethylammonium bromide; ddab) bilayer and chitosan with molecular weight (mw) of 4200 da was studied with cyclic voltammetry (cv), electrochemical impedance spectroscopy and surface plasmon resonance (spr). a lipid bilayer was formed by-fusion of oppositely charged lipid vesicles on a mercaptopropionic acid (mpa)-modified gold surface to mimic a cell membrane. the results showed that the lmw chitosan could disrupt the lipid bilayer, and the effect seemed,to be in a concentration-dependent manner. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000178222400008 |
| 公开日期 | 2010-11-03 |
| 源URL | [http://202.98.16.49/handle/322003/18327]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yang F,Cui XQ,Yang XR. Interaction of low-molecular-weight chitosan with mimic membrane studied by electrochemical methods and surface plasmon resonance[J]. biophysical chemistry,2002,99(1):99-106. |
| APA | Yang F,Cui XQ,&Yang XR.(2002).Interaction of low-molecular-weight chitosan with mimic membrane studied by electrochemical methods and surface plasmon resonance.biophysical chemistry,99(1),99-106. |
| MLA | Yang F,et al."Interaction of low-molecular-weight chitosan with mimic membrane studied by electrochemical methods and surface plasmon resonance".biophysical chemistry 99.1(2002):99-106. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。