H-1 NMR analysis for metabolites in serum and urine from rats administrated chronically with La(NO3)(3)
文献类型：期刊论文
| 作者 | Feng JH ; Li XJ ; Pei FK ; Chen X ; Li SL ; Nie YX |
| 刊名 | analytical biochemistry
 |
| 出版日期 | 2002 |
| 卷号 | 301期号:1页码:1-7 |
| 关键词 | NUCLEAR-MAGNETIC-RESONANCE H-1-NMR SPECTROSCOPY IDENTIFICATION PATTERN PLASMA |
| ISSN号 | 0003-2697 |
| 通讯作者 | pei fk |
| 中文摘要 | h-1 nmr spectroscopy has been used to assess long-term toxicological effects of a rare earth. male wistar rats were administrated orally with la(no3)(3) at doses of 0.1, 0.2, 2.0, 10, and 20 mg/kg body wt, resp., for 3-6 months. urine was collected at 1, 2, and 3 months and serum samples were taken after 6 months. numerous low-m-r metabolites in rats serum and rats urine, including creatinine, citrate, glucose, ketone bodies, trimethylamine n-oxide (tmao), and various amino acids, were identified on 400- and 500-mhz h-1 nmr spectra. la3+-induced renal and liver damage is characterized by an increase in the amounts of the excreted ketone bodies, amino acids, lactate, ethanol, succinate, tmao, dimethylamine, and taurine and a decrease in citrate, glucose, urea, and allantoin. information on the molecular basis of the long-term toxicity of la(no3)(3) was derived from the abnormal patterns of metabolite excretions. an assay of some biochemical indexes and analysis of some enzymes in plasma supported nmr results. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000173661300001 |
| 公开日期 | 2010-11-03 |
| 源URL | [http://202.98.16.49/handle/322003/18807]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng JH,Li XJ,Pei FK,et al. H-1 NMR analysis for metabolites in serum and urine from rats administrated chronically with La(NO3)(3)[J]. analytical biochemistry,2002,301(1):1-7. |
| APA | Feng JH,Li XJ,Pei FK,Chen X,Li SL,&Nie YX.(2002).H-1 NMR analysis for metabolites in serum and urine from rats administrated chronically with La(NO3)(3).analytical biochemistry,301(1),1-7. |
| MLA | Feng JH,et al."H-1 NMR analysis for metabolites in serum and urine from rats administrated chronically with La(NO3)(3)".analytical biochemistry 301.1(2002):1-7. |
入库方式： OAI收割
来源：长春应用化学研究所
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