中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Self-assembled monolayer growth of phospholipids on hydrophobic surface toward mimetic biomembranes: Scanning probe microscopy study

文献类型:期刊论文

作者Tang ZY ; Jing WG ; Wang EK
刊名langmuir
出版日期2000
卷号16期号:4页码:1696-1702
关键词ATOMIC-FORCE MICROSCOPY LANGMUIR-BLODGETT-FILMS AIR-WATER-INTERFACE QUARTZ-CRYSTAL MICROBALANCE TUNNELING-MICROSCOPY MOLECULAR-RESOLUTION LIPID BILAYER PHOSPHATIDYLCHOLINE BILAYERS INTERDIGITATED DOMAINS CHOLERA-TOXIN
ISSN号0743-7463
通讯作者wang ek
中文摘要atomic force microscopy (afm) and lateral force microscopy (lfm) were used simultaneously to analyze a model membrane bilayer structure consisting of a phospholipid outer monolayer deposited onto organosilane-derivatized mica surfaces, which were constructed by using painting and self-assembly methods. the phospholipid used as outer monolayer was dimyristoylphosphatidylcholine (dmpc). the hydrocarbon-covered substrate that formed the inner half bilayer was composed of a self-assembly monolayer (sam) of octadecyltrichloroorganosilane (ots) on mica. sams of dmpc were formed by exposing hydrophobic mica to a solution of dmpc in decane/isobutanol and subsequently immersing into pure water. afm images of samples immersed in solution for varying exposure times showed that before forming a complete monolayer the molecules aggregated into dense islands (2.2-2.6 nm high) on the surface. the islands had a compact and rounded morphology. lfm, coupled with topographic data obtained with the atomic force mode, had made possible the distinction between dmpc and ots. the rate constant of dmpc growth was calculated. this is the first systematic study of the sam formation of dmpc by afm and lfm imaging. it reveals more direct information about the film morphology than previous studies with conventional surface analytical techniques such as infrared spectroscopy, x-ray, or fluorescence microscopy.
收录类别SCI收录期刊论文
语种英语
WOS记录号WOS:000085412600033
公开日期2010-11-04
源URL[http://202.98.16.49/handle/322003/19891]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Tang ZY,Jing WG,Wang EK. Self-assembled monolayer growth of phospholipids on hydrophobic surface toward mimetic biomembranes: Scanning probe microscopy study[J]. langmuir,2000,16(4):1696-1702.
APA Tang ZY,Jing WG,&Wang EK.(2000).Self-assembled monolayer growth of phospholipids on hydrophobic surface toward mimetic biomembranes: Scanning probe microscopy study.langmuir,16(4),1696-1702.
MLA Tang ZY,et al."Self-assembled monolayer growth of phospholipids on hydrophobic surface toward mimetic biomembranes: Scanning probe microscopy study".langmuir 16.4(2000):1696-1702.

入库方式: OAI收割

来源:长春应用化学研究所

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