SeGPX activity of three organoselenium-containing cyclodextrins and their scavenging effects on HO center dot
文献类型：期刊论文
| 作者 | Ma XY ; Wu YH ; Ding L ; Zhao DQ ; Ni JZ ; Liu Y |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 1999 |
| 卷号 | 20期号:8页码:1163-1167 |
| 关键词 | GLUTATHIONE-PEROXIDASE SUPRAMOLECULAR SYSTEM SELENIUM RECOGNITION LESIONS |
| ISSN号 | 0251-0790 |
| 通讯作者 | ma xy |
| 中文摘要 | three organoselenium-containing derivatives of beta-cyclodextrins (beta-cd), mono-6-benzylseleno-6-deoxy-beta-cyclodextrin (compound 1), 6,6'-trimethylenediseleno bridged beta-cyclodextrin dimer(compound 2) and 6,6'- (o-phenylene)diseleno bridged beta-cyclodextrin dimer (compound 3) functioned as mimics of selenium-containing glutathione peroxidase(segpx). acting on h2o2 and gsh, the segpx activities of these compounds were 0.83-, 0.26-, and 1. 23-fold of that of ebselen (0.99 u/mu mol), respectively. the relationship between the structure and the function of these compounds was studied. the results suggested that the hydrophobicity and rigidity of phenyl group is the main reason that accounted for the higher activity of compounds 3 and 1. phenyl group not only provided the hydrophobic circumstance which is necessary for the catalytic function of selenium, but also make it possible that the cyclodextrin unit of compounds 1 and 3 combines the substrate with a more effective direction. fluorometric techniques were utilized to determine the yields of the hydroxyl radical produced by fenton reactions through the formation of hydroxy benzoic acids from benzoate. compared with ebselen which showed a significant inhibition effect on the formation of ho., these organoselenium-containing cyclodextrins showed a little scavenging effect on the formation of ho. throughout the whole process. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 中文 |
| WOS记录号 | WOS:000082126800001 |
| 公开日期 | 2010-11-04 |
| 源URL | [http://202.98.16.49/handle/322003/21691]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ma XY,Wu YH,Ding L,et al. SeGPX activity of three organoselenium-containing cyclodextrins and their scavenging effects on HO center dot[J]. chemical journal of chinese universities-chinese,1999,20(8):1163-1167. |
| APA | Ma XY,Wu YH,Ding L,Zhao DQ,Ni JZ,&Liu Y.(1999).SeGPX activity of three organoselenium-containing cyclodextrins and their scavenging effects on HO center dot.chemical journal of chinese universities-chinese,20(8),1163-1167. |
| MLA | Ma XY,et al."SeGPX activity of three organoselenium-containing cyclodextrins and their scavenging effects on HO center dot".chemical journal of chinese universities-chinese 20.8(1999):1163-1167. |
入库方式： OAI收割
来源：长春应用化学研究所
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