Effects of La3+ and Gd3+ on Ca2+ influx in rat hepatoma H-35 cells
文献类型：期刊论文
| 作者 | Li XM ; Fong WF ; Kwok PF ; Yang MS ; Wong PCL ; Ni JZ |
| 刊名 | chinese science bulletin
 |
| 出版日期 | 1999 |
| 卷号 | 44期号:4页码:331-335 |
| 关键词 | LANTHANIDE IONS CA-2+ CHANNELS INCREASE SYSTEM |
| ISSN号 | 1001-6538 |
| 通讯作者 | li xm |
| 中文摘要 | effects of la3+ and gd3+ on ca2+ influx were investigated in rat hepatoma h-35 cells by measuring the initial rate of ca-45(2+) uptake. it was found that the maximum initial rate of ca2+ uptake was increased six- to ten-fold at low concentrations of la3+ and gd3+. kinetic analyses by measuring the initial rate of ca2+ influx at different external ca2+ concentrations indicated the existence of two intracellular exchangeable components in the basal ca2+ system, with low and high affinities for ca2+, and only one class of ca2+ binding sites was observed in the la3+- or gd3+-treated cells. for high affinity, la3+ and gc(3+) increased both kinetic parameters k-m and v-max of basal ca2+ influx. la3+ and gd3+ compete directly with ca2+ for ca2+ binding site for low affinity. the kinetics is competitive. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000079646600011 |
| 公开日期 | 2010-11-04 |
| 源URL | [http://202.98.16.49/handle/322003/21959]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li XM,Fong WF,Kwok PF,et al. Effects of La3+ and Gd3+ on Ca2+ influx in rat hepatoma H-35 cells[J]. chinese science bulletin,1999,44(4):331-335. |
| APA | Li XM,Fong WF,Kwok PF,Yang MS,Wong PCL,&Ni JZ.(1999).Effects of La3+ and Gd3+ on Ca2+ influx in rat hepatoma H-35 cells.chinese science bulletin,44(4),331-335. |
| MLA | Li XM,et al."Effects of La3+ and Gd3+ on Ca2+ influx in rat hepatoma H-35 cells".chinese science bulletin 44.4(1999):331-335. |
入库方式： OAI收割
来源：长春应用化学研究所
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