Electrochemical studies of lipophilic ion transport through BLM. The influence of sterols on its transport
文献类型：期刊论文
| 作者 | Ding L ; Wang EK |
| 刊名 | electroanalysis
 |
| 出版日期 | 1996 |
| 卷号 | 8期号:10页码:922-926 |
| 关键词 | LIPID BILAYER MEMBRANES PHOSPHOLIPID HEAD GROUPS CHOLESTEROL PERMEABILITY PHLORETIN MECHANISM LIPOSOMES MODEL |
| ISSN号 | 1040-0397 |
| 通讯作者 | ding l |
| 中文摘要 | cyclic voltammetry was employed to study the influence of sterols on the lipophilic ion transport through the blm. the mole fraction of the sterols (cholesterol, oxidized cholesterol). as referred to total lipid, was varied in a range of 0-0.8. data demonstrate that a thin-layer model is suitable to this blm system. by this model, the number of charges transported per lipophilic ion, the concentration of the ion in the membrane bulk phase and the aqueous/membrane phase partition coefficient could be calculated. these parameters proved that sterols had an obvious influence on the lipophilic ion transport. cholesterol had a stronger influence on the ion transport than oxidized cholesterol. its incorporation into egg lecithin membranes increased the partition coefficient beta of the ion up to more than 3-fold. yet, oxidized cholesterol incorporated into egg lecithin membranes only increased the beta up to less than 2-fold, and the beta had no great variation at different oxidized cholesterol mole fractions. the higher beta obtained was partly due to the trace amount of solvent existing in the core of the lipid bilayers. at the different sterol mole fractions, combining the change of beta with the change of peak current, we also concluded that sterols had somewhat inhibiting effect on the ion transport at the higher sterols mole fraction (>0.4). these results are explained in terms of the possible change of dipole potential of the membrane produced by sterols and the decrease of the membrane fluidity caused by the condensation effect of sterols and the thinning effect caused by sterols. the substituting group (in the oxidized cholesterol) had some inhibiting effects on the ion transport at higher mole fractions (oxidized cholesterol mole fraction >0.4). |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2010-12-22 ; 2011-06-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/25173]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding L,Wang EK. Electrochemical studies of lipophilic ion transport through BLM. The influence of sterols on its transport[J]. electroanalysis,1996,8(10):922-926. |
| APA | Ding L,&Wang EK.(1996).Electrochemical studies of lipophilic ion transport through BLM. The influence of sterols on its transport.electroanalysis,8(10),922-926. |
| MLA | Ding L,et al."Electrochemical studies of lipophilic ion transport through BLM. The influence of sterols on its transport".electroanalysis 8.10(1996):922-926. |
入库方式： OAI收割
来源：长春应用化学研究所
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