STM OF FOLDED AND UNFOLDED HEMOGLOBIN MOLECULES ELECTROCHEMICALLY DEPOSITED ON HIGHLY ORIENTED PYROLYTIC-GRAPHITE
文献类型：期刊论文
| 作者 | ZHANG JD ; CHI QJ ; DONG SJ ; WANG EK |
| 刊名 | journal of the chemical society-faraday transactions
 |
| 出版日期 | 1995 |
| 卷号 | 91期号:10页码:1471-1475 |
| 关键词 | SCANNING TUNNELING MICROSCOPY TUNNELLING MICROSCOPY DNA SURFACE HEMOGLOBIN OXIDATION PROTEINS IMAGES |
| ISSN号 | 0956-5000 |
| 中文摘要 | the structural characterization of folded and unfolded haemoglobin has been performed by scanning tunnelling microscopy (stm) for the first time. stm images show an oval-shaped pattern for the folded structure of this protein, and moreover two dimers consisting of one haemoglobin molecule can be clearly discerned. the dimensions of a folded molecule were determined as 6.4 x 5.4 x 0.7 nm(3), which are in good agreement with the known size obtained from x-ray analysis. we have found that unfolding of haemoglobin molecules on the surface of highly oriented pyrolytic graphite (hopg) can be achieved by electrochemical deposition. the stm analysis indicates clearly that the tertiary structure of the protein was lost by electrochemical deposition, and most of the haemoglobin molecules were almost fully extended and exhibited a twisted rope-like or a rod-like aggregated structure. our investigation demonstrates the capability of the electrochemical method in denaturing this redox protein and in preparing stable biological samples for use in stm imaging. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2010-12-30 ; 2011-06-10 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/26617]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | ZHANG JD,CHI QJ,DONG SJ,et al. STM OF FOLDED AND UNFOLDED HEMOGLOBIN MOLECULES ELECTROCHEMICALLY DEPOSITED ON HIGHLY ORIENTED PYROLYTIC-GRAPHITE[J]. journal of the chemical society-faraday transactions,1995,91(10):1471-1475. |
| APA | ZHANG JD,CHI QJ,DONG SJ,&WANG EK.(1995).STM OF FOLDED AND UNFOLDED HEMOGLOBIN MOLECULES ELECTROCHEMICALLY DEPOSITED ON HIGHLY ORIENTED PYROLYTIC-GRAPHITE.journal of the chemical society-faraday transactions,91(10),1471-1475. |
| MLA | ZHANG JD,et al."STM OF FOLDED AND UNFOLDED HEMOGLOBIN MOLECULES ELECTROCHEMICALLY DEPOSITED ON HIGHLY ORIENTED PYROLYTIC-GRAPHITE".journal of the chemical society-faraday transactions 91.10(1995):1471-1475. |
入库方式： OAI收割
来源：长春应用化学研究所
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