Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro
文献类型：期刊论文
| 作者 | Suo, Yourui1; Li, Gang3; Wang, Honglun1,2; Wang, Zhenhua3; Luan, Guangxiang1,4; Li, Ji3; Yuan, Zhenzhen1,4; Hao, Xueyan3 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2017-06-01 |
| 卷号 | 14期号:6 |
| 关键词 | Potentilla parvifolia FISCH. Flavonoids Neuroprotective effects SH-SY5Y cells Tau phosphorylation |
| 英文摘要 | Potentilla parvifolia FISCH. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH-SY5Y cells were differentiated with all trans-retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | RETINOIC ACID ; INDUCED NEUROTOXICITY ; ALZHEIMERS-DISEASE ; AGRIMONIA-PILOSA ; DIFFERENTIATION ; ACTIVATION ; APOPTOSIS ; TAU ; ANTIOXIDANT ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000405126900021 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/7075]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China 2.Qinghai Univ, State Key Lab Plateau Ecol & Agr, Xining 810008, Peoples R China 3.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Suo, Yourui,Li, Gang,Wang, Honglun,et al. Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro[J]. CHEMISTRY & BIODIVERSITY,2017,14(6). |
| APA | Suo, Yourui.,Li, Gang.,Wang, Honglun.,Wang, Zhenhua.,Luan, Guangxiang.,...&Hao, Xueyan.(2017).Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro.CHEMISTRY & BIODIVERSITY,14(6). |
| MLA | Suo, Yourui,et al."Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro".CHEMISTRY & BIODIVERSITY 14.6(2017). |
入库方式： OAI收割
来源：西北高原生物研究所
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