Population transcriptomes reveal synergistic responses of DNA polymorphism and RNA expression to extreme environments on the Qinghai-Tibetan Plateau in a predatory bird
文献类型：期刊论文
| 作者 | Pan, Shengkai1,2,13; Zhang, Tongzuo12; Rong, Zhengqin11; Hu, Li2,10,13; Zhan, Xiangjiang1,2; Bruford, Michael W.1,3; Dixon, Andrew1,4,5; Deutschova, Lucia6; Li, Xinhai2; Lin, Zhenzhen2 |
| 刊名 | MOLECULAR ECOLOGY
 |
| 出版日期 | 2017-06-01 |
| 卷号 | 26期号:11页码:2993-3010 |
| 关键词 | adaptation colonization population transcriptome Qinghai-Tibetan Plateau RNA sequencing saker falcon |
| 英文摘要 | Low oxygen and temperature pose key physiological challenges for endotherms living on the Qinghai-Tibetan Plateau (QTP). Molecular adaptations to high-altitude living have been detected in the genomes of Tibetans, their domesticated animals and a few wild species, but the contribution of transcriptional variation to altitudinal adaptation remains to be determined. Here we studied a top QTP predator, the saker falcon, and analysed how the transcriptome has become modified to cope with the stresses of hypoxia and hypothermia. Using a hierarchical design to study saker populations inhabiting grassland, steppe/desert and highland across Eurasia, we found that the QTP population is already distinct despite having colonized the Plateau <2000years ago. Selection signals are limited at the cDNA level, but of only seventeen genes identified, three function in hypoxia and four in immune response. Our results show a significant role for RNA transcription: 50% of upregulated transcription factors were related to hypoxia responses, differentiated modules were significantly enriched for oxygen transport, and importantly, divergent EPAS1 functional variants with a refined co-expression network were identified. Conservative gene expression and relaxed immune gene variation may further reflect adaptation to hypothermia. Our results exemplify synergistic responses between DNA polymorphism and RNA expression diversity in coping with common stresses, underpinning the successful rapid colonization of a top predator onto the QTP. Importantly, molecular mechanisms underpinning highland adaptation involve relatively few genes, but are nonetheless more complex than previously thought and involve fine-tuned transcriptional responses and genomic adaptation. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology |
| 关键词[WOS] | PRINCIPAL COMPONENT ANALYSIS ; INDUCIBLE FACTOR-I ; HIGH-ALTITUDE ; DIFFERENTIAL EXPRESSION ; GENOME SCANS ; IMMUNE-RESPONSE ; R PACKAGE ; SEQ DATA ; HYPOXIA ; ADAPTATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402040000013 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/7094]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Cardiff Univ, Inst Zool, Joint Lab Biocomplex Res, Beichen West Rd, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beichen West Rd, Beijing 100101, Peoples R China 3.Cardiff Univ, Cardiff Sch Biosci, Organisms & Environm Div, Cardiff CF10 3AX, S Glam, Wales 4.Environm Agcy Abu Dhabi, POB 45553,Al Mamoura Bldg A,Muroor Rd, Abu Dhabi, U Arab Emirates 5.Int Wildlife Consultants Ltd, POB 19, Carmarthen SA33 5YL, Dyfed, Wales 6.Raptor Protect Slovakia, Kuklovska 5, SK-84104 Bratislava 4, Slovakia 7.Beijing Normal Univ, Coll Life Sci, MOE Key Lab Biodivers Sci & Ecol Engn, Beijing 100875, Peoples R China 8.Beijing Normal Univ, Coll Life Sci, State Key Lab Earth Surface Proc & Resource Ecol, Beijing 100875, Peoples R China 9.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China 10.BGI Shenzhen, Shenzhen 518083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Shengkai,Zhang, Tongzuo,Rong, Zhengqin,et al. Population transcriptomes reveal synergistic responses of DNA polymorphism and RNA expression to extreme environments on the Qinghai-Tibetan Plateau in a predatory bird[J]. MOLECULAR ECOLOGY,2017,26(11):2993-3010. |
| APA | Pan, Shengkai.,Zhang, Tongzuo.,Rong, Zhengqin.,Hu, Li.,Zhan, Xiangjiang.,...&Wu, Qi.(2017).Population transcriptomes reveal synergistic responses of DNA polymorphism and RNA expression to extreme environments on the Qinghai-Tibetan Plateau in a predatory bird.MOLECULAR ECOLOGY,26(11),2993-3010. |
| MLA | Pan, Shengkai,et al."Population transcriptomes reveal synergistic responses of DNA polymorphism and RNA expression to extreme environments on the Qinghai-Tibetan Plateau in a predatory bird".MOLECULAR ECOLOGY 26.11(2017):2993-3010. |
入库方式： OAI收割
来源：西北高原生物研究所
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