Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways
文献类型：期刊论文
| 作者 | Jiang, Lei5; Zhao, Xiaoying2,3,4; Pei, Jinjin1,5; Mei, Lijuan5; Cui, Yulei5,6; Wang, Shuo5,6; Shao, Yun5; Zhang, Xiaoling2,3,4; Tao, Yanduo5 |
| 刊名 | JOURNAL OF FUNCTIONAL FOODS
 |
| 出版日期 | 2017-10-01 |
| 卷号 | 37页码:594-602 |
| 关键词 | Evodiamine Zanthoxylum bungeanum RANKL Osteoclast differentiation ERK NFATc1 |
| 英文摘要 | Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, attenuates RANKL-induced OC formation, the expression level of OC-specific marker genes and OC marker protein in vitro. Mechanistically, evodiamine dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1, which is essential for OC formation. These data suggest that evodiamine might be a useful alternative therapy in preventing or treating osteolytic diseases. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Food Science & Technology |
| 研究领域[WOS] | Food Science & Technology |
| 关键词[WOS] | BONE LOSS ; CANCER ; PROLIFERATION ; APOPTOSIS ; OSTEOPOROSIS ; RESORPTION ; CALCIUM ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000412863400060 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/9828]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Shaanxi Univ Technol, Shaanxi Key Lab Bioresources & Biol, Hanzhong 723001, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med SJTUSM, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China 5.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Lei,Zhao, Xiaoying,Pei, Jinjin,et al. Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways[J]. JOURNAL OF FUNCTIONAL FOODS,2017,37:594-602. |
| APA | Jiang, Lei.,Zhao, Xiaoying.,Pei, Jinjin.,Mei, Lijuan.,Cui, Yulei.,...&Tao, Yanduo.(2017).Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways.JOURNAL OF FUNCTIONAL FOODS,37,594-602. |
| MLA | Jiang, Lei,et al."Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways".JOURNAL OF FUNCTIONAL FOODS 37(2017):594-602. |
入库方式： OAI收割
来源：西北高原生物研究所
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