Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque in human coronary artery at 16 frames per second
文献类型：期刊论文
| 作者 | Hui, Jie; Cao, Yingchun; Zhang, Yi; Kole, Ayeeshik; Wang, Pu; Yu, Guangli; Eakins, Gregory; Sturek, Michael; Chen, Weibiao; Cheng, Ji-Xin |
| 刊名 | Sci Rep
 |
| 出版日期 | 2017 |
| 卷号 | 7 |
| 通讯作者 | jcheng@purdue.edu |
| 英文摘要 | Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipid-laden plaques, as it provides simultaneous morphological and lipid-specific chemical information of an artery wall. Real-time imaging and display at video-rate speed are critical for clinical utility of the IVPA-US imaging technology. Here, we demonstrate a portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging speed was achieved by concurrent innovations in excitation laser source, rotary joint assembly, 1 mm IVPA-US catheter size, differentiated A-line strategy, and real-time image processing and display algorithms. Spatial resolution, chemical specificity, and capability for imaging highly dynamic objects were evaluated by phantoms to characterize system performance. An imaging speed of 16 frames per second was determined to be adequate to suppress motion artifacts from cardiac pulsation for in vivo applications. The translational capability of this system for the detection of lipid-laden plaques was validated by ex vivo imaging of an atherosclerotic human coronary artery at 16 frames per second, which showed strong correlation to gold-standard histopathology. Thus, this high-speed IVPA-US imaging system presents significant advances in the translational intravascular and other endoscopic applications. |
| 资助信息 | AHA Postdoctoral Fellowship; IUPUI Graduate Student Imaging Research Fellowship; [R01HL125385] |
| 收录类别 | SCI |
| WOS记录号 | WOS:000400491100018 |
| 源URL | [http://ir.siom.ac.cn/handle/181231/28418]  |
| 专题 | 上海光学精密机械研究所_空间激光信息技术研究中心 |
| 作者单位 | 中国科学院上海光学精密机械研究所 |
| 推荐引用方式 GB/T 7714 | Hui, Jie,Cao, Yingchun,Zhang, Yi,et al. Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque in human coronary artery at 16 frames per second[J]. Sci Rep,2017,7. |
| APA | Hui, Jie.,Cao, Yingchun.,Zhang, Yi.,Kole, Ayeeshik.,Wang, Pu.,...&Cheng, Ji-Xin.(2017).Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque in human coronary artery at 16 frames per second.Sci Rep,7. |
| MLA | Hui, Jie,et al."Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque in human coronary artery at 16 frames per second".Sci Rep 7(2017). |
入库方式： OAI收割
来源：上海光学精密机械研究所
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