Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?
文献类型：期刊论文
| 作者 | Xie, Peng; Zhang, Yan |
| 刊名 | THEORETICAL CHEMISTRY ACCOUNTS
 |
| 出版日期 | 2016-12-19 |
| 卷号 | 136期号:1 |
| 关键词 | Congenital stationary night blindness Retinal isomers QM/MM Thermal stability Thermal isomerization barrier |
| 英文摘要 | The thermal stability and thermal activity of four G90D rhodopsin isomer models were investigated by QM/MM method. The results implied that one pathological mechanism of congenital stationary night blindness caused by G90D mutation is the low thermal isomerization barrier of G90D rhodopsin binding with 11-cis retinal, not just the lacking of natural salt bridge. 9-cis retinal binding with G90D rhodopsin opsin could increase the thermal stability and minimize the thermal isomerization of G90D rhodopsin mutant. Therefore, 9-cis retinal was suggested to be used in potential treatments for congenital stationary night blindness caused by G90D mutation. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | VISUAL PIGMENT ; 7-CIS ISOMERS ; MUTATION ; MECHANISM ; PROTEIN ; PHOTOISOMERIZATION ; ACTIVATION ; MUTANTS ; PHOTORECEPTOR ; ISORHODOPSIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000406775500001 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/149820]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Peng,Zhang, Yan. Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?[J]. THEORETICAL CHEMISTRY ACCOUNTS,2016,136(1). |
| APA | Xie, Peng,&Zhang, Yan.(2016).Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?.THEORETICAL CHEMISTRY ACCOUNTS,136(1). |
| MLA | Xie, Peng,et al."Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?".THEORETICAL CHEMISTRY ACCOUNTS 136.1(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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