Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export
文献类型：期刊论文
| 作者 | Fan, Jing4; Kuai, Bin4; Wu, Guifen4; Wu, Xudong2; Chi, Binkai4; Wang, Lantian4; Wang, Ke4; Shi, Zhubing4; Zhang, Heng4; Chen, She3 |
| 刊名 | EMBO JOURNAL
 |
| 出版日期 | 2017-10-02 |
| 卷号 | 36期号:19页码:2870-2886 |
| 关键词 | ALYREF ARS2 hMTR4 mRNA export nuclear RNA degradation |
| 英文摘要 | The exosome is a key RNA machine that functions in the degradation of unwanted RNAs. Here, we found that significant fractions of precursors and mature forms of mRNAs and long noncoding RNAs are degraded by the nuclear exosome in normal human cells. Exosome-mediated degradation of these RNAs requires its cofactor hMTR4. Significantly, hMTR4 plays a key role in specifically recruiting the exosome to its targets. Furthermore, we provide several lines of evidence indicating that hMTR4 executes this role by directly competing with the mRNA export adaptor ALYREF for associating with ARS2, a component of the cap-binding complex (CBC), and this competition is critical for determining whether an RNA is degraded or exported to the cytoplasm. Together, our results indicate that the competition between hMTR4 and ALYREF determines exosome recruitment and functions in creating balanced nuclear RNA pools for degradation and export. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | INTRONLESS MESSENGER-RNAS ; CAP-BINDING COMPLEX ; HUMAN TREX COMPLEX ; SACCHAROMYCES-CEREVISIAE ; POLY(A) POLYMERASE ; TARGETING COMPLEX ; MAMMALIAN-CELLS ; QUALITY-CONTROL ; II TRANSCRIPTS ; RIBOSOMAL-RNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000412115800007 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/150170]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Mol Modeling & Design, State Key Lab Mol React Dynam, Dalian, Peoples R China 3.Natl Inst Biol Sci, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, State Key Lab Mol Biol,Shanghai Inst Biochem & Ce, Shanghai Key Lab Mol Androl,CAS Ctr Excellence Mo, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Jing,Kuai, Bin,Wu, Guifen,et al. Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export[J]. EMBO JOURNAL,2017,36(19):2870-2886. |
| APA | Fan, Jing.,Kuai, Bin.,Wu, Guifen.,Wu, Xudong.,Chi, Binkai.,...&Cheng, Hong.(2017).Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export.EMBO JOURNAL,36(19),2870-2886. |
| MLA | Fan, Jing,et al."Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export".EMBO JOURNAL 36.19(2017):2870-2886. |
入库方式： OAI收割
来源：大连化学物理研究所
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