Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)
文献类型：期刊论文
| 作者 | Ni, Chunfang3; Lian, Ru1,3; Wu, Zhongping3; Lv, Xiaobao3; Rao, Yulan4; Li, Haiyang2; Li, Jinghua2; Wang, Rong3; Zhang, Yurong3 |
| 刊名 | FORENSIC SCIENCE INTERNATIONAL
 |
| 出版日期 | 2017-10-01 |
| 卷号 | 279页码:268-280 |
| 关键词 | Drugs of abuse DAPP-IMS Reduced mobility DART-TOF-MS Rapid screening |
| 英文摘要 | Increasing in cases involving drugs of abuse leads to heavy burden for law enforcement agencies, exacerbating demand for rapid screening technique. In this study, atmospheric pressure ionization technologies including direct analysis in real time (DART) ion source coupled to a time-of-flight mass spectrometer (DART-TOF-MS) as well asdopant-assisted positive photoionization ion mobility spectrometry (DAPP-IMS) without radioactivity were utilized together as the powerful analytical tool for the rapid screening and identification of 53 abused drugs. The limits of detection (LOD) were 0.05-2 mu g/mL when using DART-TOF-MS and 0.02-2 mu g when using DAPP-IMS which could satisfy the actual requirement in forensic science laboratory. The advantages of this method included fast response, high-throughput potential, high specificity, and minimal sample preparation. A screening library of reduced mobility (K-0), accurate mass of informative precursor ion ([M+H](+)) and fragment ions was established respectively by employing a bench-top DAPP-IMS and TOF-MS in-source collision induced dissociation (CID) mode. Then the standardized screening procedure was developed with criteria for the confirmation of positive result. A total of 50 seized drug samples provided by local forensic laboratory we reanalyzed to testify the utility of the method. This study suggests that a method combing DART-TOF-MS and DAPP-IMS is promising for the rapid screening and identification of abused drugs with minimal sample preparation and absence of chromatography. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Legal |
| 研究领域[WOS] | Legal Medicine |
| 关键词[WOS] | PSYCHOACTIVE SUBSTANCES ; SYNTHETIC CANNABINOIDS ; ACCUTOF-DART ; IDENTIFICATION ; VALIDATION ; ACCUTOF-DART(TM) ; QUANTIFICATION ; EXPLOSIVES ; DESORPTION ; CATHINONES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000411904200038 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/150196]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shanghai Inst Pharmaceut Ind, China State Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 3.Shanghai Inst Forens Sci, Shanghai Key Lab Crime Scene Evidence, Shanghai, Peoples R China 4.Fudan Univ, Sch Basic Med Sci, Dept Forens Med, Ctr Forens Sci, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ni, Chunfang,Lian, Ru,Wu, Zhongping,et al. Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)[J]. FORENSIC SCIENCE INTERNATIONAL,2017,279:268-280. |
| APA | Ni, Chunfang.,Lian, Ru.,Wu, Zhongping.,Lv, Xiaobao.,Rao, Yulan.,...&Zhang, Yurong.(2017).Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS).FORENSIC SCIENCE INTERNATIONAL,279,268-280. |
| MLA | Ni, Chunfang,et al."Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)".FORENSIC SCIENCE INTERNATIONAL 279(2017):268-280. |
入库方式： OAI收割
来源：大连化学物理研究所
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