Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization
文献类型：期刊论文
| 作者 | Sun, Jing-yang2; Rong, Jing-jing2; Liang, Ming2; Xuan, Feng-qi2; Zhao, Li-jun2; Zheng, Hui-zhen1; Tian, Xiao-xiang2; Liu, Dan2; Zhang, Quan-yu2; Peng, Cheng-fei2 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 104页码:1302-1312 |
| 关键词 | Alginate Thrombin Microsphere Transcatheter Embolization Hemostasis |
| 英文摘要 | Transcatheter arterial embolization (TAE) is the best non-laparotomy choice for solid visceral organs rupture and bleeding nowadays. In our previous study, a new biodegradable macromolecule material thrombin-loaded alginate-calcium microsphere (TACM) was prepared and its characteristics were investigated preliminarily. In this study, we further investigated the biocompatibility of TACMs, as well as physical characteristic, application method and effect of TACMs with thrombus (embolic agent). The in vivo results attested that TACMs were non-irritating and non-genotoxic with desired biocompatibility, although brought about a slight and temporary inflammation. Application research showed that the function of thrombin was inhibited by common contrast agents, and it was impracticable to add contrast agents in TACMs with thrombus for tracing under X-rays in TAE. Then, a novel delivery method was developed. In addition, stress resistance test indicated that the TACMs with thrombus was significantly stronger than single autologous thrombus, the optimized ratio of TACMs to whole blood was 2:3 for forming mixed thrombus. Finally, large animal experiment revealed that the novel embolic agent TACMs mixed thrombus was effective and safe in treating hemorrhage of solid abdominal viscera by TAE. (C) 2017 Published by Elsevier B.V. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 关键词[WOS] | BLUNT SPLENIC TRAUMA ; PROTEIN-C PATHWAY ; POSTPARTUM HEMORRHAGE ; CONTRAST AGENTS ; INJURY ; MANAGEMENT ; CYTOTOXICITY ; EXPERIENCE ; EFFICACY ; NECROSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000412959300145 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/150228]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Gen Hosp Shenyang Mil Reg, Dept Cardiol, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jing-yang,Rong, Jing-jing,Liang, Ming,et al. Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,104:1302-1312. |
| APA | Sun, Jing-yang.,Rong, Jing-jing.,Liang, Ming.,Xuan, Feng-qi.,Zhao, Li-jun.,...&Yu, Wei-ting.(2017).Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,104,1302-1312. |
| MLA | Sun, Jing-yang,et al."Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 104(2017):1302-1312. |
入库方式： OAI收割
来源：大连化学物理研究所
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