An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry
文献类型：期刊论文
| 作者 | Liu, Huwei1; Zhang, Yiding1; Ai, Wanpeng1; Bai, Yu1; Zhou, Yinglin1; Wen, Luhong2; Zhang, Xinxiang1 |
| 刊名 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 408期号:30页码:8655-8661 |
| 关键词 | Dielectric barrier discharge ionization Capillary electrophoresis Ambient mass spectrometry Interface |
| 英文摘要 | The online combination of capillary electrophoresis (CE) with mass spectrometry (MS) has long been desired for the capability of direct and simultaneous separation and detection with high efficiency, accuracy, and throughput. In this work, a novel CE-MS interface was developed, using dielectric barrier discharge ionization (DBDI). The interface employed a spray tip with a coaxial three-layer structure, into which the CE sample solution, the sheath liquid, and the nebulizing gas were introduced. The spray tip was put between the DBDI outlet and the MS inlet, thus the CE sample solution could be blended with the sheath liquid, then nebulized. The nebulized sample could be ionized by DBDI, and finally analyzed by MS. The key parameters of the interface were optimized. Then, proof-of-concept experiments separating and detecting the mixture of metronidazole and acetaminophen solutions were conducted. The results showed high separation efficiency, low time consumption, high reproducibility, and convenience in operation. In addition, the interface exhibited a high tolerance of non-volatile salts and surfactants, which would be widely used in CE analyses. All of these results demonstrated that the newly developed CE-DBDI-MS interface could be successfully used in CE-MS studies, and could be further utilized in multiple areas involving efficient separation and detection. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Chemistry, Analytical |
| 关键词[WOS] | SURFACE-PLASMON RESONANCE ; ELECTROSPRAY-IONIZATION ; ION-SOURCE ; COMBINATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000389605400009 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/150439]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Inst Analyt Chem,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China 2.Ningbo Univ, Res Inst Adv Technol, Ningbo 315211, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Huwei,Zhang, Yiding,Ai, Wanpeng,et al. An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2016,408(30):8655-8661. |
| APA | Liu, Huwei.,Zhang, Yiding.,Ai, Wanpeng.,Bai, Yu.,Zhou, Yinglin.,...&Zhang, Xinxiang.(2016).An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,408(30),8655-8661. |
| MLA | Liu, Huwei,et al."An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 408.30(2016):8655-8661. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。