Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters
文献类型：期刊论文
| 作者 | Liu, Yang1; Lee, Robert J.1,3; Wang, Juan1; Wang, Di1; Liu, Chungang1; Xu, Shiqi1; An, Shengshu1; Tang, Siying1; He, Jian2 |
| 刊名 | MOLECULAR MEDICINE REPORTS
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 16期号:2页码:2172-2178 |
| 关键词 | Paecilomyces tenuipes chronic unpredictable mild stress antidepression neurotransmitters |
| 英文摘要 | The medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)-induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antidepressant-like activity of P. tenuipes N45 aqueous extract (PTNE) in a CUMS-induced rat model of behavioral despair depression. Following 4 weeks of PTNE treatment, behavioral tests were conducted to investigate the antidepressant-like activities, and the levels of neurotransmitters and hormones in blood and hypothalamus were measured. The results demonstrated that PTNE treatment significantly increased movement in the forced running test, whereas the immobility time was reduced in the hotplate test and the forced swim test in depression-model rats. PTNE treatment was able to normalize the levels of hormones and neurotransmitters in serum and hypothalamus of CUMS rats. The data demonstrated that PTNE treatment may be a potential pharmaceutical agent in treatment-resistant depression, and the effects of PTNE may be partly mediated through normalizing the levels of neurotransmitters. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Oncology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Oncology ; Research & Experimental Medicine |
| 关键词[WOS] | BIOACTIVE COMPOUNDS ; DOPAMINE RELEASE ; MOUSE MODEL ; MICE ; SYSTEM ; ANTIDEPRESSANTS ; DISORDERS ; DISEASE ; AXIS ; EXPRESSION |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000405079300153 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/151905]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jilin Univ, Sch Life Sci, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Ctr Translat Med, Dalian 116023, Liaoning, Peoples R China 3.Ohio State Univ, Coll Pharm, Div Pharmaceut, 500 West 12th Ave, Columbus, OH 43201 USA |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Lee, Robert J.,Wang, Juan,et al. Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters[J]. MOLECULAR MEDICINE REPORTS,2017,16(2):2172-2178. |
| APA | Liu, Yang.,Lee, Robert J..,Wang, Juan.,Wang, Di.,Liu, Chungang.,...&He, Jian.(2017).Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters.MOLECULAR MEDICINE REPORTS,16(2),2172-2178. |
| MLA | Liu, Yang,et al."Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters".MOLECULAR MEDICINE REPORTS 16.2(2017):2172-2178. |
入库方式： OAI收割
来源：大连化学物理研究所
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