Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites
文献类型：期刊论文
| 作者 | Tu, Cai-Xia2; Liang, Si-Cheng1,2,3; Ge, Guang-Bo1; Xia, Yang-Liu1; Dong, Pei-Pei4; Wang, Ping1; Qi, Xiao-Yi1,2; Yang, Ling1 |
| 刊名 | XENOBIOTICA
 |
| 出版日期 | 2017-06-01 |
| 卷号 | 47期号:6页码:498-504 |
| 关键词 | Daphnetin COMT inhibitor 8-O-methyldaphnetin ligand-protein interaction Phase II metabolite structural modification |
| 英文摘要 | 1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several potent COMT inhibitors reported previously. Here the potential of daphnetin and its Phase II metabolites as inhibitors of COMT was investigated with human liver cytosol (HLC). |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | TANDEM MASS-SPECTROMETRY ; UDP-GLUCURONOSYLTRANSFERASES ; BIOACTIVITY ANALYSIS ; PHENOLIC-COMPOUNDS ; GLUCURONIDATION ; TOLCAPONE ; LIVER ; RAT ; COMT ; ENTACAPONE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000399917500005 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/151986]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 2, 467 Zhongshan Rd, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 4.Dalian Med Univ, Coll Pharm, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tu, Cai-Xia,Liang, Si-Cheng,Ge, Guang-Bo,et al. Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites[J]. XENOBIOTICA,2017,47(6):498-504. |
| APA | Tu, Cai-Xia.,Liang, Si-Cheng.,Ge, Guang-Bo.,Xia, Yang-Liu.,Dong, Pei-Pei.,...&Yang, Ling.(2017).Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites.XENOBIOTICA,47(6),498-504. |
| MLA | Tu, Cai-Xia,et al."Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites".XENOBIOTICA 47.6(2017):498-504. |
入库方式： OAI收割
来源：大连化学物理研究所
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