Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents
文献类型：期刊论文
| 作者 | Ge Guangbo2; Chen Chen1; Wang Ping2; Zou Liwei2; Yang Ling2; Fan Yiming2; Hu Wenzhong1 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 33期号:2页码:194-199 |
| 关键词 | Hydroxylcoumarin Antioxidant activity Radical scavenging effect Structure-activity relationship |
| 英文摘要 | In this study, esculetin(1) was chosen as a lead compound and some structural modifications were designed to explore the antioxidant activities of esculetin derivatives. Meanwhile, a convenient method for selective methylation of catechol coumarins with different bases was developed. Furthermore, a few 5,7-dihydroxylcoumarins were synthesized and 7-hydroxylcoumarins were employed in order to explore the potential structure-antioxidant activity relationships. The antioxidant activities of these compounds were evaluated and compared with standard antioxidant Trolox by the 2,2'-diphenyl-1-picrylhydrazyl(DPPH) assay, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation(ABTS(+)) assay and ferric reducing antioxidant power(FRAP) assay. The results show that the catechol group is the key pharmacophore. Meanwhile, introducing electronegative groups at the C4 position of esculetin(1) may enhance the antioxidative capacity, while introducing a group containing nitrogen as a hydrogen bond acceptor at the C8 position may slightly reduce the antioxidative capacity. Among them, the most powerful antioxidants are compounds 5 and 7, which exhibit higher antioxidant activity than esculetin(1) in all assays. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | COUMARINS ; POWER ; SEEDS ; ASSAY ; FRAP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000399867100007 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/152000]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Minzu Univ, Coll Life Sci, Dalian 116600, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge Guangbo,Chen Chen,Wang Ping,et al. Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(2):194-199. |
| APA | Ge Guangbo.,Chen Chen.,Wang Ping.,Zou Liwei.,Yang Ling.,...&Hu Wenzhong.(2017).Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,33(2),194-199. |
| MLA | Ge Guangbo,et al."Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 33.2(2017):194-199. |
入库方式： OAI收割
来源：大连化学物理研究所
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