Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow
文献类型：期刊论文
| 作者 | Du Y(杜宇) ; Peng S(彭爽); Cui Yuhong; Lv SQ(吕守芹); Zhang Y(章燕); Long M(龙勉)
|
| 刊名 | Theoretical and Applied Mechanics Letters
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:6页码:216-221 |
| 关键词 | Cell Adhesion Aggregation Kinetics Shear Flow |
| ISSN号 | 2095-0349 |
| 文献子类 | Article |
| 英文摘要 | Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor-ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate (or shear stress) and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor-ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5590448 |
| 资助机构 | supported by National Natural Science Foundation of China ; National Key Basic Research Foundation of China ; Strategic Priority Research Program |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/60781]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 推荐引用方式 GB/T 7714 | Du Y,Peng S,Cui Yuhong,et al. Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow[J]. Theoretical and Applied Mechanics Letters,2015,5(6):216-221. |
| APA | 杜宇,彭爽,Cui Yuhong,吕守芹,章燕,&龙勉.(2015).Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow.Theoretical and Applied Mechanics Letters,5(6),216-221. |
| MLA | 杜宇,et al."Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow".Theoretical and Applied Mechanics Letters 5.6(2015):216-221. |
入库方式： OAI收割
来源：力学研究所
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