During operational cycles of heating and cooling of submarine pipelines, variations of temperature and internal pressure may induce excessive axial compressive force along the pipeline and lead to global buckling of the pipeline. Reliable design against upheaval buckling of a buried pipeline requires the uplift response to be reasonably predicted. Under wave loading, the effective stress of soil could be reduced significantly in the seabed under wave troughs. To investigate the effects of wave-induced pore-pressure on the soil resistance to an uplifted buried pipeline, a poro-elastoplastic model is proposed, which is capable of simulating the wave-induced pore-pressure response in a porous seabed and the development of plastic zones while uplifting a shallowly-buried pipeline. The uplift force on the buried pipeline under wave troughs can be generated by the pore-pressure nonuniformly distributed along the pipe periphery. Numerical results show that the value of uplift force generally increases linearly with the wave induced mudline pressure under troughs. Parametric study indicates that the peak soil resistance (under wave troughs) decreases with increasing wave height and wave period, respectively. The ratio of peak soil resistance under wave action to that without waves is mainly dependent on the normalized wave-induced mudline pressure, but influenced slightly by the internal friction angle of soil.