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Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis

文献类型：期刊论文

作者Wang, Rong1; Wu, Hong1; Chen, Jian2; Li, Shu-Ping1; Dai, Li1; Zhang, Zheng-Rong1; Wang, Wen-Yu1
刊名PHYTOTHERAPY RESEARCH
出版日期2017-04-01
卷号31期号:4页码:631-637
关键词Geniposide Mesenteric Lymph Node Lymphocytes Inflammation Erk1/2 Signaling Pathway
DOI10.1002/ptr.5775
文献子类Article
英文摘要Geniposide (GE), an iridoid glycoside compound purified from Gardenia jasminoides Ellis, has antiinflammatory and other pharmacological effects, but its mechanism of actions on rheumatoid arthritis (RA) have not been clarified. The purpose of this article was to investigate the pharmacological effects of GE on collagen-induced arthritis (CIA) rats and its feasible mechanisms. Collagen-induced arthritis was induced by injection of chicken type II collagen emulsion. The rats were orally administered with GE (33, 66, and 132 mg/kg) from days 14 to 30 after immunization. The histological examination showed that GE could attenuate histopathologic changes of mesenteric lymph node (MLN) in CIA rats. Geniposide inhibited the production of Interleukin 6 (IL-6) and IL-17, while promoting the production of IL-4 and transforming growth factor-beta 1 in MLN lymphocytes (MLNLs). Moreover, the proliferation capability of MLNLs was increased after the administration of GE. In addition, the treatment with GE in vivo decreased the expressions of P-Raf, P-MEK, and P-Erk1/2 in MLNLs. These results may highlight the antiinflammatory effects and possible mechanisms of GE in MLNLs of RA. Copyright (c) 2017 John Wiley & Sons, Ltd.
WOS关键词MUCOSAL IMMUNE-SYSTEM ; RHEUMATOID-ARTHRITIS ; ADJUVANT ARTHRITIS ; GARDENIA-JASMINOIDES ; JOINT DAMAGE ; B-CELLS ; SINOMENINE ; IL-6 ; DIFFERENTIATION ; INFLAMMATION
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000398604300008
资助机构National Natural Science Foundation of China(81473400) ; National Natural Science Foundation of China(81473400) ; National Natural Science Foundation of China(81473400) ; National Natural Science Foundation of China(81473400) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z) ; National Natural Science Foundation of China(81473400) ; National Natural Science Foundation of China(81473400) ; National Natural Science Foundation of China(81473400) ; National Natural Science Foundation of China(81473400) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z) ; Anhui Provincial Natural Science Research Project in Colleges and Universities(KJ2009A045Z)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/31825]  
专题合肥物质科学研究院_中科院安徽光学精密机械研究所
作者单位1.Anhui Univ Chinese Med, Coll Pharm, Key Lab Modernized Chinese Med Anhui Prov, Hefei 230012, Anhui, Peoples R China
2.Univ Sci & Technol China, Anhui Inst Opt & Fine Mech, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Rong,Wu, Hong,Chen, Jian,et al. Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis[J]. PHYTOTHERAPY RESEARCH,2017,31(4):631-637.
APA Wang, Rong.,Wu, Hong.,Chen, Jian.,Li, Shu-Ping.,Dai, Li.,...&Wang, Wen-Yu.(2017).Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis.PHYTOTHERAPY RESEARCH,31(4),631-637.
MLA Wang, Rong,et al."Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis".PHYTOTHERAPY RESEARCH 31.4(2017):631-637.

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来源：合肥物质科学研究院

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