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1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells

文献类型：期刊论文

作者Zhang, Lei1,2; Yang, Xingxing1; Liu, Juanjuan1,2; Luo, Yan1; Li, Zhiyuan1; Ji, Xinmiao1; Wang, Wenchao1; Zhang, Xin1
刊名SCIENCE BULLETIN
出版日期2015-12-01
卷号60期号:24页码:2120-2128
关键词Static Magnetic Field Cell Proliferation Mtor Mtor Inhibitor Feedback Reactivation
DOI10.1007/s11434-015-0950-5
文献子类Article
英文摘要Static magnetic field (SMF) has been known to affect cell proliferation in a cell-type-dependent manner, while the mechanism still remains unclear. We found that 1 T moderate intensity SMF inhibits cell proliferation of nasopharyngeal carcinoma CNE-2Z cells and the Akt/ mTOR signaling pathway, which is upregulated in many cancers. mTOR inhibitors are potential chemodrugs, but their clinical effects are limited by the feedback reactivation of other signaling components such as EGFR and Akt. We showed that 1 T SMF increases the antitumor efficacy of mTOR inhibitor Torin 2. In addition, 1 T SMF increases the inhibition efficiency on mTOR substrates phosphorylation and represses the mTOR inhibitor-induced feedback reactivation of EGFR and Akt. Our study not only demonstrates that mTOR/Akt pathway is one of the molecular targets of SMFs in cells, but also reveals the clinical potentials of combinations of mTOR inhibitors and SMFs in cancer treatment.
WOS关键词PI3K/AKT/MTOR PATHWAY ; LUNG-CANCER ; IN-VITRO ; EXPOSURE ; GROWTH ; PROLIFERATION ; AZD8055 ; TARGET ; RICTOR
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000367400300005
资助机构Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22219]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Lei,Yang, Xingxing,Liu, Juanjuan,et al. 1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells[J]. SCIENCE BULLETIN,2015,60(24):2120-2128.
APA Zhang, Lei.,Yang, Xingxing.,Liu, Juanjuan.,Luo, Yan.,Li, Zhiyuan.,...&Zhang, Xin.(2015).1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells.SCIENCE BULLETIN,60(24),2120-2128.
MLA Zhang, Lei,et al."1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells".SCIENCE BULLETIN 60.24(2015):2120-2128.

入库方式： OAI收割

来源：合肥物质科学研究院

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