中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 中科院合肥智能机械研究所
Tunable nanogap devices for ultra-sensitive electrochemical impedance biosensing

文献类型：期刊论文

作者Lu, Yong1; Guo, Zheng2; Song, Jing-Jing1; Huang, Qin-An1; Zhu, Si-Wei1; Huang, Xing-Jiu2; Wei, Yan1
刊名ANALYTICA CHIMICA ACTA
出版日期2016-01-28
卷号905期号:无页码:58-65
关键词Tunable Nanogap Devices Streptavidin Electrochemical Impedance Ultra-sensitive Electron-transfer Resistance
DOI10.1016/j.aca.2015.11.036
文献子类Article
英文摘要A wealth of research has been available discussing nanogap devices for detecting very small quantities of biomolecules by observing their electrical behavior generally performed in dry conditions. We report that a gold nanogapped electrode with tunable gap length for ultra-sensitive detection of streptavidin based on electrochemical impedance technique. The gold nanogap is fabricated using simple monolayer film deposition and in-situ growth of gold nanoparticles in a traditional interdigitated array (IDA) microelectrode. The electrochemical impedance biosensor with a 25-nm nanogap is found to be ultra-sensitive to the specific binding of streptavidin to biotin. The binding of the streptavidin hinder the electron transfer between two electrodes, resulting in a large increase in electron-transfer resistance (R-et) for operating the impedance. A linear relation between the relative R-et and the logarithmic value of streptavidin concentration is observed in the concentration range from 1 pM (picomolar) to 100 nM (nanomolar). The lowest detectable concentration actually measured reaches 1 pM. We believe that such an electrochemical impedance nanogap biosensor provides a useful approach towards biomolecular detection that could be extended to a number of other systems. (C) 2015 Elsevier B.V. All rights reserved.
WOS关键词GOLD PARTICLE FILM ; ESCHERICHIA-COLI O157-H7 ; ELECTRICAL DETECTION ; NANOPARTICLE ARRAY ; DNA-HYBRIDIZATION ; SENSOR ARRAY ; IMMUNOSENSOR ; ELECTRODE ; SPECTROSCOPY ; TRANSPORT
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000367395000006
资助机构National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National natural Science Foundation of China(21105073) ; National natural Science Foundation of China(21105073) ; National natural Science Foundation of China(21105073) ; National natural Science Foundation of China(21105073) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; University outstanding youth talent support program of Anhui Province ; University outstanding youth talent support program of Anhui Province ; University outstanding youth talent support program of Anhui Province ; University outstanding youth talent support program of Anhui Province ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008) ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008) ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008) ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008) ; National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National Key Scientific Program-Nanoscience and Nanotechnology(2011CB933700) ; National natural Science Foundation of China(21105073) ; National natural Science Foundation of China(21105073) ; National natural Science Foundation of China(21105073) ; National natural Science Foundation of China(21105073) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; Project of Educational Committee of Anhui Province(KJ2010B240) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; State Key Laboratory of Electroanalytical Chemistry(SKLEAC201307) ; University outstanding youth talent support program of Anhui Province ; University outstanding youth talent support program of Anhui Province ; University outstanding youth talent support program of Anhui Province ; University outstanding youth talent support program of Anhui Province ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008) ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008) ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008) ; CAS Institute of Physical Science, University of Science and Technology of China(2012FXCX008)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22225]  
专题合肥物质科学研究院_中科院合肥智能机械研究所
作者单位1.Wannan Med Coll, Dept Chem, Wuhu 241002, Peoples R China
2.Chinese Acad Sci, Inst Intelligent Machines, Nanomat & Environm Detect Lab, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Yong,Guo, Zheng,Song, Jing-Jing,et al. Tunable nanogap devices for ultra-sensitive electrochemical impedance biosensing[J]. ANALYTICA CHIMICA ACTA,2016,905(无):58-65.
APA Lu, Yong.,Guo, Zheng.,Song, Jing-Jing.,Huang, Qin-An.,Zhu, Si-Wei.,...&Wei, Yan.(2016).Tunable nanogap devices for ultra-sensitive electrochemical impedance biosensing.ANALYTICA CHIMICA ACTA,905(无),58-65.
MLA Lu, Yong,et al."Tunable nanogap devices for ultra-sensitive electrochemical impedance biosensing".ANALYTICA CHIMICA ACTA 905.无(2016):58-65.

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。