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Osteochondral repair with synovial membrane-derived mesenchymal stem cells

文献类型：期刊论文

作者Li, Hong1; Qian, Junchao2; Chen, Jiwu1; Zhong, Kai2; Chen, Shiyi1
刊名MOLECULAR MEDICINE REPORTS
出版日期2016-03-01
卷号13期号:3页码:2071-2077
关键词Cartilage Synovial Mesenchymal Stem Cells Magnetic Resonance Imaging
DOI10.3892/mmr.2016.4795
文献子类Article
英文摘要The aim of the present study was to analyze cartilage repair tissue quality following synovial membrane-derived mesenchymal stem cell (SMSC) transplantation in a rabbit osteochondral defect. A total of 15 New Zealand white rabbits were randomly distributed into three groups (n=5 in each group). In group 1, an osteochondral defect model was established in the right knee trochlea, prior to transplantation with SMSCs (SMSC group). In group 2, an osteochondral defect model was established without further treatment (control group). Group 3 did not undergo osteochondral defect model establishment and served as the sham control (normal group). All animals were sacrificed 12 weeks following the surgical procedures for magnetic resonance imaging and histological examination. No significant differences were observed between the control and SMSC group in the macroscopic score (P>0.05), the 2D magnetic resonance observation of cartilage repair tissue score (P>0.05) or the modified O'Driscoll scale (P>0.05). Compared with the control group, a significant improvement in tissue quality was observed in the SMSCs group postoperatively. The repair tissue of the SMSCs group had a shorter T-2, compared with that of the control group, although no significant difference was detected (P>0.05). Furthermore, the apparent diffusion coefficient in the repair tissue of the SMSC group had a significantly lower value, compared with that of the control group (P=0.016). The results of the present study demonstrated that osteochondral repair using SMSCs facilitated the repair of appropriate tissue texture.
WOS关键词AUTOLOGOUS CHONDROCYTE TRANSPLANTATION ; NORMAL HYALINE CARTILAGE ; ARTICULAR-CARTILAGE ; REPARATIVE TISSUE ; CHONDRAL DEFECTS ; T2 ASSESSMENT ; KNEE-JOINT ; MICROFRACTURE ; MATRIX ; MODEL
WOS研究方向Oncology ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000371633000017
资助机构Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; Shanghai Municipal Science and Technology Commission(1052nm03701 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; National Natural Science Foundation of China(81201068 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 11nm0504900 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 81472142 ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 11JC1401700) ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; 81401812 ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212) ; U1232212)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22326]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Huashan Hosp, Dept Sports Med, 12 Wulumuyi Zhong Rd, Shanghai 200040, Peoples R China
2.Chinese Acad Sci, High Field Magnet Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Li, Hong,Qian, Junchao,Chen, Jiwu,et al. Osteochondral repair with synovial membrane-derived mesenchymal stem cells[J]. MOLECULAR MEDICINE REPORTS,2016,13(3):2071-2077.
APA Li, Hong,Qian, Junchao,Chen, Jiwu,Zhong, Kai,&Chen, Shiyi.(2016).Osteochondral repair with synovial membrane-derived mesenchymal stem cells.MOLECULAR MEDICINE REPORTS,13(3),2071-2077.
MLA Li, Hong,et al."Osteochondral repair with synovial membrane-derived mesenchymal stem cells".MOLECULAR MEDICINE REPORTS 13.3(2016):2071-2077.

入库方式： OAI收割

来源：合肥物质科学研究院

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