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Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5-FU and Taxol

文献类型：期刊论文

作者Luo, Yan1; Ji, Xinmiao1; Liu, Juanjuan1,2; Li, Zhiyuan1; Wang, Wenchao1; Chen, Wei1; Wang, Junfeng1,2; Liu, Qingsong1,2; Zhang, Xin1
刊名BIOELECTROCHEMISTRY
出版日期2016-06-01
卷号109期号:无页码:31-40
关键词Static Magnetic Field Microtubule Mitosis Cancer Cells 5-fluorouracil Cisplatin
DOI10.1016/j.bioelechem.2016.01.001
文献子类Article
英文摘要Microtubules are the fundamental components in mitotic spindle, which plays essential roles in cell division. It was well known that purified microtubules could be affected by static magnetic fields (SMFs) in vitro because of the diamagnetic anisotropy of tubulin. However, whether these effects lead to cell division defects was unknown. Here we find that 1 T SMFs induce abnormal mitotic spindles and increase mitotic index. Synchronization experiments show that SMFs delay cell exit from mitosis and cause mitotic arrest. These mimic the cellular effects of a microtubule-targeting drug Paclitaxel (Taxol), which is frequently used in combination with 5-Fluorouracil (5-FU) and Cisplatin in cancer treatment. Using four different human cancer cell lines, HeLa, HCT116, CNE-2Z and MCF7, we find that SMFs increase the antitumor efficacy of 5-FU or 5-FU/Taxol, but not Cisplatin, which indicates that the SMF-induced combinational effects with chemodrugs are drug-specific. Our study not only reveals the effect of SMFs on microtubules to cause abnormal mitotic spindles and delay cells exit from mitosis, but also implies the potential applications of SMFs in combination with chemotherapy drugs 5-FU or 5-FU/Taxol, but not with Cisplatin in cancer treatment. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词IN-VIVO ; CANCER-CHEMOTHERAPY ; MICROTUBULES ; CISPLATIN ; EXPOSURE ; GROWTH ; CELLS ; ANGIOGENESIS ; INHIBITION ; TUBULIN
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Biophysics ; Electrochemistry
语种英语
WOS记录号WOS:000373418400004
资助机构Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22352]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Chinese Acad Sci, High Field Magnet Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Luo, Yan,Ji, Xinmiao,Liu, Juanjuan,et al. Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5-FU and Taxol[J]. BIOELECTROCHEMISTRY,2016,109(无):31-40.
APA Luo, Yan.,Ji, Xinmiao.,Liu, Juanjuan.,Li, Zhiyuan.,Wang, Wenchao.,...&Zhang, Xin.(2016).Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5-FU and Taxol.BIOELECTROCHEMISTRY,109(无),31-40.
MLA Luo, Yan,et al."Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5-FU and Taxol".BIOELECTROCHEMISTRY 109.无(2016):31-40.

入库方式： OAI收割

来源：合肥物质科学研究院

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