Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases
文献类型：期刊论文
| 作者 | Wang, Wei1,4 ; Hirano, Yoshinori2; Uzawa, Takanori1,3; Taiji, Makoto2; Ito, Yoshihiro1,3
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| 刊名 | BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
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| 出版日期 | 2016-04-15 |
| 卷号 | 89期号:4页码:444-446 |
| DOI | 10.1246/bcsj.20150414 |
| 文献子类 | Article |
| 英文摘要 | Conjugation of small molecular inhibitor with a site recognition peptide would generate highly potent peptide drug conjugate inhibitors of protein kinases. A peptide selected by ribosome display with a tRNA carrying an inhibitor conjugated amino acid exhibited up to 10- to 100-fold higher inhibitory effects towards different kinases than solely the inhibitor. |
| WOS关键词 | IN-VITRO SELECTION ; APTAMER ; RNA ; RECOGNITION ; LIBRARY ; DESIGN |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000374275900005 |
| 资助机构 | Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/22360]  |
| 专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
| 作者单位 | 1.RIKEN, Nano Med Engn Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan 2.RIKEN, Quantitat Biol Ctr, Lab Computat Mol Design, Computat Biol Res Core,Chou Ku, 1-6-5 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan 3.RIKEN, Ctr Emergent Matter Sci, Emergent Bioengn Mat Res Team, 2-1 Hirosawa, Wako, Saitama 3510198, Japan 4.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wei,Hirano, Yoshinori,Uzawa, Takanori,et al. Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,2016,89(4):444-446. |
| APA | Wang, Wei,Hirano, Yoshinori,Uzawa, Takanori,Taiji, Makoto,&Ito, Yoshihiro.(2016).Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases.BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,89(4),444-446. |
| MLA | Wang, Wei,et al."Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases".BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 89.4(2016):444-446. |
入库方式： OAI收割
来源：合肥物质科学研究院
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