中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 中科院强磁场科学中心
Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances

文献类型：期刊论文

作者Liu, Xiaochuan1,2; Wang, Aoli2,3; Liang, Xiaofei2,4; Chen, Cheng2,4; Liu, Juanjuan2,3; Zhao, Zheng2,4; Wu, Hong2,3; Deng, Yuanxin2,3; Wang, Li2,4; Wang, Beilei2,4
刊名ONCOTARGET
出版日期2016-05-31
卷号7期号:22页码:32641-32651
关键词Pi3k Delta Leukemia B-cell Malignances Pi3k Kinase Inhibitors
DOI10.18632/oncotarget.8702
文献子类Article
英文摘要PI3K delta is predominately expressed in leukocytes and has been found overexpressed in B-cell related malignances such as CLL and AML. We have discovered a highly selective ATP competitive PI3K delta inhibitor PI3KD-IN-015, which exhibits a high selectivity among other PI3K isoforms in both biochemical assays and cellular assay, meanwhile did not inhibit most of other protein kinases in the kinome. PI3KD-IN-015 demonstrates moderately anti-proliferation efficacies against a variety of B-cell related cancer cell lines through down-regulate the PI3K signaling significantly. It induced both apoptosis and autophagy in B-cell malignant cell lines. In addition, combination of autophagy inhibitor Bafilomycin could potentiate the moderate antiproliferation effect of PI3KD-IN-015. PI3KD-IN-015 shows anti-proliferation efficacy against CLL and AML patient primary cells. Collectively, these results indicate that PI3KD-IN-015 may be useful drug candidate for further development of anti-B-cell related malignances therapies.
WOS关键词CHRONIC LYMPHOCYTIC-LEUKEMIA ; PI3K ; P110-DELTA ; IDELALISIB ; 3-KINASES ; SURVIVAL ; ISOFORM ; CANCER
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000377748500078
资助机构Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; Anhui Province Natural Science Foundation Annual Key Program(1301023011) ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; China "Thousand Talents Program" ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; "Hundred Talents Program" of The Chinese Academy of Sciences ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; Scientific Research Grant of Hefei Science Center of CAS (SRG-HSC)(2015SRG-HSC022) ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams ; CAS/SAFEA international partnership program for creative research teams
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22446]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Univ Sci & Technol China, Dept Chem, Hefei 230036, Anhui, Peoples R China
2.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
3.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China
4.CHMFL HCMTC Target Therapy Joint Lab, Hefei 230031, Anhui, Peoples R China
5.Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, 44 Binney St, Boston, MA 02115 USA
6.Hefei Cosource Med Technol Co LTD, Hefei 230031, Anhui, Peoples R China
7.Chinese Acad Sci, Hefei Sci Ctr, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xiaochuan,Wang, Aoli,Liang, Xiaofei,et al. Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances[J]. ONCOTARGET,2016,7(22):32641-32651.
APA Liu, Xiaochuan.,Wang, Aoli.,Liang, Xiaofei.,Chen, Cheng.,Liu, Juanjuan.,...&Liu, Qingsong.(2016).Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances.ONCOTARGET,7(22),32641-32651.
MLA Liu, Xiaochuan,et al."Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances".ONCOTARGET 7.22(2016):32641-32651.

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。