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G protein. subunit 7 induces autophagy and inhibits cell division

文献类型：期刊论文

作者Liu, Juanjuan1,2; Ji, Xinmiao1; Li, Zhiyuan1; Yang, Xingxing1; Wang, Wenchao1; Zhang, Xin1
刊名ONCOTARGET
出版日期2016-04-26
卷号7期号:17页码:24832-24847
关键词Gng7 (g Protein Gamma Subunit 7) Autophagy Cell Death Cell Division Actin
DOI10.18632/oncotarget.8559
文献子类Article
英文摘要GNG7 (G protein gamma subunit 7), a subunit of heterotrimeric G protein, is ubiquitously expressed in multiple tissues but is down-regulated in various cancers. Its expression could reduce tumor volume in mice but the mechanism was not clear. Here we show that GNG7 overexpression inhibits cell proliferation and increases cell death. GNG7 level is cell cycle-dependent and it regulates actin cytoskeleton and cell division. In addition, GNG7 is an autophagy inducer, which is the first reported G gamma protein involved in autophagy. GNG7 knockdown reduces Rapamycin and starvation-induced autophagy. Further analysis reveals that GNG7 inhibits MTOR in cells, a central regulator for autophagy and cell proliferation. In conclusion, GNG7 inhibits MTOR pathway to induce autophagy and cell death, inhibits cell division by regulating actin cytoskeleton. These combined effects lead to the antitumor capacity of GNG7.
WOS关键词HETEROTRIMERIC G-PROTEINS ; G-BETA-GAMMA ; ALPHA-INTERACTING PROTEIN ; CAENORHABDITIS-ELEGANS ; HT-29 CELLS ; CANCER ; ACTIN ; ORIENTATION ; SPINDLE ; LOCALIZATION
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000377706200144
资助机构Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22450]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Juanjuan,Ji, Xinmiao,Li, Zhiyuan,et al. G protein. subunit 7 induces autophagy and inhibits cell division[J]. ONCOTARGET,2016,7(17):24832-24847.
APA Liu, Juanjuan,Ji, Xinmiao,Li, Zhiyuan,Yang, Xingxing,Wang, Wenchao,&Zhang, Xin.(2016).G protein. subunit 7 induces autophagy and inhibits cell division.ONCOTARGET,7(17),24832-24847.
MLA Liu, Juanjuan,et al."G protein. subunit 7 induces autophagy and inhibits cell division".ONCOTARGET 7.17(2016):24832-24847.

入库方式： OAI收割

来源：合肥物质科学研究院

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