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A cyanine-based near-infrared fluorescent probe for highly sensitive and selective detection of hypochlorous acid and bioimaging

文献类型：期刊论文

作者Li, Huihui1,2; Guan, Lingmei3; Zhang, Xiaojie3; Yu, Huan1; Huang, Dejian4; Sun, Mingtai1; Wang, Suhua1,2
刊名TALANTA
出版日期2016-12-01
卷号161期号:无页码:592-598
关键词Fluorescent Near-infrared Hypochlorous Acid Cell Imaging
DOI10.1016/j.talanta.2016.09.008
文献子类Article
英文摘要Hypochlorous acid (HOCl) is a kind of reactive oxygen species which plays an important role in biological process. HOCl detection is of great importance in disease prevention and treatment. Herein, a cyanine-based near-infrared (NIR) fluorescent probe for HOC! has been designed and synthesized. This probe can react with HOC! in a dose-response manner along with the fluorescence of the probe quenched, the reaction through an electrophilic addition to the double bond and subsequent oxidation reaction. Experiments indicate that the probe can be acted as a selective and sensitive indicator for HOCl and the limit of detection for HOC! is estimated to be 22 nM. What's more, this probe shows a low toxicity to cells and can be applied to visualize HOCl molecules in living cells. Therefore, the proposed method may make a significant contribution to HOCl detection. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词QUANTUM DOTS ; SCAVENGING ACTIVITY ; NITRIC-OXIDE ; LIVING CELLS ; DYES ; CHEMILUMINESCENCE ; QUANTIFICATION ; OXIDATION ; CHLORINE ; SULFIDE
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000386989500076
资助机构National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; National Natural Science Foundation of China(21302187 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101) ; 91439101)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/30793]  
专题合肥物质科学研究院_中科院合肥智能机械研究所
作者单位1.Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
4.Natl Univ Singapore, Dept Chem, Food Sci & Technol Programme, 3 Sci Dr 3, Singapore 117543, Singapore
推荐引用方式
GB/T 7714		 Li, Huihui,Guan, Lingmei,Zhang, Xiaojie,et al. A cyanine-based near-infrared fluorescent probe for highly sensitive and selective detection of hypochlorous acid and bioimaging[J]. TALANTA,2016,161(无):592-598.
APA Li, Huihui.,Guan, Lingmei.,Zhang, Xiaojie.,Yu, Huan.,Huang, Dejian.,...&Wang, Suhua.(2016).A cyanine-based near-infrared fluorescent probe for highly sensitive and selective detection of hypochlorous acid and bioimaging.TALANTA,161(无),592-598.
MLA Li, Huihui,et al."A cyanine-based near-infrared fluorescent probe for highly sensitive and selective detection of hypochlorous acid and bioimaging".TALANTA 161.无(2016):592-598.

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来源：合肥物质科学研究院

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