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  4. 中科院合肥智能机械研究所
A single dual-emissive nanofluorophore test paper for highly sensitive colorimetry-based quantification of blood glucose

文献类型：期刊论文

作者Huang, Xiaoyan2; Zhou, Yujie2; Liu, Cui3; Zhang, Ruilong1,3; Zhang, Liying2; Du, Shuhu2; Liu, Bianhua1,3; Han, Ming-Yong3; Zhang, Zhongping1,3,4
刊名BIOSENSORS & BIOELECTRONICS
出版日期2016-12-15
卷号86期号:无页码:530-535
关键词Ratiometric Fluorescent Probe Test Paper Colorimetric Quantification Blood Glucose
DOI10.1016/j.bios.2016.07.021
文献子类Article
英文摘要Fluorescent test papers are promising for the wide applications in the assays of diagnosis, environments and foods, but unlike classical dye-absorption-based pH test paper, they are usually limited in the qualitative yes/no type of detection by fluorescent brightness, and the colorimetry-based quantification remains a challenging task. Here, we report a single dual-emissive nanofluorophore probe to achieve the consecutive color variations from blue to red for the quantification of blood glucose on its as-prepared test papers. Red quantum dots were embedded into silica nanoparticles as a stable internal standard emission, and blue carbon dots (CDs) were further covalently linked onto the surface of silica, in which the ratiometric fluorescence intensity of blue to red is controlled at 5:1. While the oxidation of glucose induced the formation of Fe3+ ions, the blue emission of CDs was thus quenched by the electron transfer from CDs to Feat, displaying a serial of consecutive color variations from blue to red with the dosage of glucose. The high-quality test papers printed by the probe ink exhibited a dosage-sensitive allochromatic capability with the clear differentiations of 5, 7, 9, 11 mM glucose in human serum (normal: 3-8 mM). The blood glucose determined by the test paper was almost in accordance with that measured by a standard glucometer. The method reported here opens a window to the wide applications of fluorescent test paper in biological assays. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词QUANTUM DOTS ; LIVING CELLS ; CARBON DOTS ; FLUORESCENCE ; DISCRIMINATION ; VISUALIZATION ; DIAGNOSIS ; SENSORS ; CANCER ; PROBE
WOS研究方向Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:000384853300074
资助机构National Natural Science Foundation of China(21275075 ; National Natural Science Foundation of China(21275075 ; National Natural Science Foundation of China(21275075 ; National Natural Science Foundation of China(21275075 ; National Basic Research Program of China(2015CB932002) ; National Basic Research Program of China(2015CB932002) ; National Basic Research Program of China(2015CB932002) ; National Basic Research Program of China(2015CB932002) ; China-Singapore Joint Project(2015DFG92510) ; China-Singapore Joint Project(2015DFG92510) ; China-Singapore Joint Project(2015DFG92510) ; China-Singapore Joint Project(2015DFG92510) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; 21335006 ; 21335006 ; 21335006 ; 21335006 ; 21475135 ; 21475135 ; 21475135 ; 21475135 ; 21375131 ; 21375131 ; 21375131 ; 21375131 ; 21275145) ; 21275145) ; 21275145) ; 21275145) ; National Natural Science Foundation of China(21275075 ; National Natural Science Foundation of China(21275075 ; National Natural Science Foundation of China(21275075 ; National Natural Science Foundation of China(21275075 ; National Basic Research Program of China(2015CB932002) ; National Basic Research Program of China(2015CB932002) ; National Basic Research Program of China(2015CB932002) ; National Basic Research Program of China(2015CB932002) ; China-Singapore Joint Project(2015DFG92510) ; China-Singapore Joint Project(2015DFG92510) ; China-Singapore Joint Project(2015DFG92510) ; China-Singapore Joint Project(2015DFG92510) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Science and Technology Service Network Initiative(KFJ-SW-STS-172) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; Natural Science Foundation of Anhui Province(1408085MKL52) ; 21335006 ; 21335006 ; 21335006 ; 21335006 ; 21475135 ; 21475135 ; 21475135 ; 21475135 ; 21375131 ; 21375131 ; 21375131 ; 21375131 ; 21275145) ; 21275145) ; 21275145) ; 21275145)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/30798]  
专题合肥物质科学研究院_中科院合肥智能机械研究所
作者单位1.Anhui Univ, Sch Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China
2.Nanjing Med Univ, Sch Pharm, Nanjing 211166, Jiangsu, Peoples R China
3.Chinese Acad Sci, Inst Intelligent Machines, CAS Ctr Excellence Nanosci, Hefei 230031, Anhui, Peoples R China
4.Chinese Acad Sci, State Key Lab Transducer Technol, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Xiaoyan,Zhou, Yujie,Liu, Cui,et al. A single dual-emissive nanofluorophore test paper for highly sensitive colorimetry-based quantification of blood glucose[J]. BIOSENSORS & BIOELECTRONICS,2016,86(无):530-535.
APA Huang, Xiaoyan.,Zhou, Yujie.,Liu, Cui.,Zhang, Ruilong.,Zhang, Liying.,...&Zhang, Zhongping.(2016).A single dual-emissive nanofluorophore test paper for highly sensitive colorimetry-based quantification of blood glucose.BIOSENSORS & BIOELECTRONICS,86(无),530-535.
MLA Huang, Xiaoyan,et al."A single dual-emissive nanofluorophore test paper for highly sensitive colorimetry-based quantification of blood glucose".BIOSENSORS & BIOELECTRONICS 86.无(2016):530-535.

入库方式： OAI收割

来源：合肥物质科学研究院

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