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Dual-emissive fluorescence measurements of hydroxyl radicals using a coumarin-activated silica nanohybrid probe

文献类型：期刊论文

作者Liu, Saisai1,2,3; Zhao, Jun1,3; Zhang, Kui1,3; Yang, Lei4; Sun, Mingtai1,3; Yu, Huan1,3; Yan, Yehan1,3; Zhang, Yajun5; Wu, Lijun5; Wang, Suhua1,3
刊名ANALYST
出版日期2016
卷号141期号:7页码:2296-2302
DOI10.1039/c5an02261d
文献子类Article
英文摘要This work reports a novel dual-emissive fluorescent probe based on dye hybrid silica nanoparticles for ratiometric measurement of the hydroxyl radical ((OH)-O-center dot). In the probe sensing system, the blue emission of coumarin dye (coumarin-3-carboxylic acid, CCA) immobilized on the nanoparticle surface is selectively enhanced by (OH)-O-center dot due to the formation of a coumarin hydroxylation product with strong fluorescence, whereas the emission of red fluorescent dye encapsulated in the silica nanoparticle is insensitive to (OH)-O-center dot as a self-referencing signal, and so the probe provides a good quantitative analysis based on ratiometric fluorescence measurement with a detection limit of 1.65 mu M. Moreover, the probe also shows high selectivity for (OH)-O-center dot determination against metal ions, other reactive oxygen species and biological species. More importantly, it exhibits low cytotoxicity and high biocompatibility in living cells, and has been successfully used for cellular imaging of (OH)-O-center dot, showing its promising application for monitoring of intracellular (OH)-O-center dot signaling events.
WOS关键词SENSITIVE ELECTROCHEMICAL DETECTION ; REACTIVE OXYGEN ; QUANTUM DOTS ; LIVING CELLS ; RATIOMETRIC FLUORESCENCE ; BIOLOGICAL-SYSTEMS ; NMR DETECTION ; NANOPARTICLES ; GENERATION ; QUANTIFICATION
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000372657900020
资助机构National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; National Natural Science Foundation of China(91439101 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21475134 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21507135 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21302187 ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120) ; 21205120)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/30901]  
专题合肥物质科学研究院_中科院合肥智能机械研究所
作者单位1.Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, State Key Lab Transducer Technol, Hefei 230031, Anhui, Peoples R China
4.Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA
5.Chinese Acad Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Saisai,Zhao, Jun,Zhang, Kui,et al. Dual-emissive fluorescence measurements of hydroxyl radicals using a coumarin-activated silica nanohybrid probe[J]. ANALYST,2016,141(7):2296-2302.
APA Liu, Saisai.,Zhao, Jun.,Zhang, Kui.,Yang, Lei.,Sun, Mingtai.,...&Wang, Suhua.(2016).Dual-emissive fluorescence measurements of hydroxyl radicals using a coumarin-activated silica nanohybrid probe.ANALYST,141(7),2296-2302.
MLA Liu, Saisai,et al."Dual-emissive fluorescence measurements of hydroxyl radicals using a coumarin-activated silica nanohybrid probe".ANALYST 141.7(2016):2296-2302.

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来源：合肥物质科学研究院

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