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Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays

文献类型：期刊论文

作者Zhou, Binbin1,2; Li, Xiaoyun1,2; Tang, Xianghu1,2; Li, Pan1,2; Yang, Liangbao1,2; Liu, Jinhuai1,2
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2017-03-01
卷号9期号:8页码:7772-7779
关键词Interface Self-assemble Serrs Epinephrine Serum
DOI10.1021/acsami.6b15205
文献子类Article
英文摘要Target analyte detection in complex systems with high selectivity and repeatability is crucial to analytical technology and science. Here we present a two-dimensional (2D) surface-enhanced resonance Raman scattering (SERRS) platform, which takes advantages of the high selectivity of the SERRS sensor as well as the sensitivity and reproducibility of the interfacial SERS platform, for detecting trace epinephrine (EP) in the serum. To realize sensitive and selective detection of EP in a complex system, Au NPs are modified with ccEgnitriloacetic acid and Fe(NO3)(3) to form the Au NP-(Fe-NTA) sensor, and as a consequence, EP can be rapidly captured by the sensor on the surface of Au NPs and then delivered at the cyclohexane/water interface. More importantly, we synthesized the extremely stable Au NPs (PVP-stabilized Au NPs), where the presence of PVP prevents aggregation of Au NPs during the self-assembly process and then makes a more uniform distribution of Au NPs with analytes at the cyclohexane/water interface, approximately 2 nm interparticle distance between the Au NPs, which has been proved by synchrotron radiation grazing incidence small-angle X-ray scattering (SR-GISAXS) experiments. The self assembly method not only effectively avoids the aggregation of Au NPs and decreases the influence of the background signal but also can capture and enrich EP molecules in the cyclohexane/water interface, realizing the sensitive and selective detection of EP in complex serum sample. This strategy overcomes the difficulty of bringing nanostructures together to form efficient interparticle distance with simple fabrication and maximum uniformity and also provides a powerful nanosensor for tracing amounts of analyte molecules in a complex system with the advantages of capturing and enriching of target molecules in the liquid/liquid interface during the self-assembly process. Our SERRS platform opens vast possibilities for repeatability, sensitivity, and selectivity detection of targets in various complex fields.
WOS关键词LIQUID-LIQUID INTERFACES ; ASCORBIC-ACID ; DOPAMINE ; SPECTROSCOPY ; SENSITIVITY ; MONOLAYER ; SUBSTRATE ; ELECTRODE ; SIZE ; DNA
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000395494200124
资助机构National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; 21505138) ; 21505138) ; 21505138) ; 21505138)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/31790]  
专题合肥物质科学研究院_中科院合肥智能机械研究所
作者单位1.Chinese Acad Sci, Inst Intelligent Machines, Hefei, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Chem, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Appl, Shanghai Synchrotron Radiat Fac, Shanghai, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Binbin,Li, Xiaoyun,Tang, Xianghu,et al. Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(8):7772-7779.
APA Zhou, Binbin,Li, Xiaoyun,Tang, Xianghu,Li, Pan,Yang, Liangbao,&Liu, Jinhuai.(2017).Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays.ACS APPLIED MATERIALS & INTERFACES,9(8),7772-7779.
MLA Zhou, Binbin,et al."Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays".ACS APPLIED MATERIALS & INTERFACES 9.8(2017):7772-7779.

入库方式： OAI收割

来源：合肥物质科学研究院

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