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Upregulation of Mineralocorticoid Receptor in the Hypothalamus Associated with a High Anxiety-like Level in Apolipoprotein E4 Transgenic Mice

文献类型：期刊论文

作者Meng, Fan-Tao2; Zhao, Jun2,3; Fang, Hui2; Zhang, Li-Feng2; Wu, Hui-Mei4; Liu, Ya-Jing1,2
刊名BEHAVIOR GENETICS
出版日期2017-07-01
卷号47期号:4页码:416-424
关键词Apolipoprotein e Mineralocorticoid Receptor Glucocorticoid Receptor Corticotropin Releasing Factor Hypothalamic-pituitary-adrenal Axis Anxiety-like
DOI10.1007/s10519-017-9843-5
文献子类Article
英文摘要Anxiety symptoms occur in a large portion of Alzheimer's disease (AD) patients. ApolipoproteinE-4 (ApoE epsilon 4 allele), a risk factor for AD, has been recognized as an important contributor to psychiatric disorders. In the present study, we aimed to investigate the corticosterone level in relation to anxiety-like behavior changes in transgenic male mice with different glial fibrillary acidic protein (GFAP)-ApoE isoforms. GFAP-ApoE4 transgenic mice aged 3 months showed higher anxiety-like behavior in open field, light-dark box and elevated plus maze tasks compared with that of age-matched GFAP-ApoE3 mice. However, corticotropin releasing factor levels in the hypothalamus and plasma corticosterone secretion were similar in GFAP-ApoE3 and GFAP-ApoE4 transgenic male mice. Additionally, increased expression of the mineralocorticoid receptor (MR) and unchanged expression of the glucocorticoid receptor were observed in the hypothalamus of GFAP-ApoE4 mice. However, no significant differences were found in the expression levels of the MR in GFAP-ApoE3 and GFAP-ApoE4 mice at postnatal day 2. In conclusion, we found that MR upregulation rather than corticosterone level changes in the early stage of adulthood was associated with the higher anxiety-like level measured in GFAP-ApoE4 mice.
WOS关键词PROBABLE ALZHEIMERS-DISEASE ; ELEVATED PLUS-MAZE ; GLUCOCORTICOID-RECEPTOR ; FEMALE MICE ; NEUROPSYCHIATRIC SYMPTOMS ; APOE(-/-) MICE ; E-KNOCKOUT ; OVEREXPRESSION ; EXPRESSION ; BEHAVIOR
WOS研究方向Behavioral Sciences ; Genetics & Heredity ; Psychology
语种英语
WOS记录号WOS:000403569500005
资助机构National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; National Natural Science Foundation of China(31200802) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32) ; Natural Science Foundation of Anhui Province(1608085QB32)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/31985]  
专题合肥物质科学研究院_中科院合肥智能机械研究所
作者单位1.Anhui Med Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Brain Funct & Dis, Hefei 230027, Anhui, Peoples R China
3.Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
4.Anhui Med Univ, Anhui Geriatr Inst, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Meng, Fan-Tao,Zhao, Jun,Fang, Hui,et al. Upregulation of Mineralocorticoid Receptor in the Hypothalamus Associated with a High Anxiety-like Level in Apolipoprotein E4 Transgenic Mice[J]. BEHAVIOR GENETICS,2017,47(4):416-424.
APA Meng, Fan-Tao,Zhao, Jun,Fang, Hui,Zhang, Li-Feng,Wu, Hui-Mei,&Liu, Ya-Jing.(2017).Upregulation of Mineralocorticoid Receptor in the Hypothalamus Associated with a High Anxiety-like Level in Apolipoprotein E4 Transgenic Mice.BEHAVIOR GENETICS,47(4),416-424.
MLA Meng, Fan-Tao,et al."Upregulation of Mineralocorticoid Receptor in the Hypothalamus Associated with a High Anxiety-like Level in Apolipoprotein E4 Transgenic Mice".BEHAVIOR GENETICS 47.4(2017):416-424.

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来源：合肥物质科学研究院

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