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Gas modifier assisted re-circulation mode high-field asymmetric waveform ion mobility spectrometry (FAIMS)

文献类型：期刊论文

作者Ruan, Zhiming1,2; Chen, Chilai1; Chen, Ran3; Liu, Youjiang1; Wang, Xiaozhi4; Li, Shan1; Yu, Jianwen1
刊名INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
出版日期2017-03-01
卷号414期号:无页码:8-12
DOI10.1016/j.ijms.2016.12.013
文献子类Article
英文摘要In a regular FAIMS system, a carrier gas is used to drive samples through the drift tube. Thus, high consumption of sample and carrier gas can be expected, especially when multi-cycle detection is needed for high precision detection. In this study, a novel re-circulation mode FAIMS was developed. Ion separation capacity and limit of detection (LOD) of this FAIMS system were investigated. The stability of this FAIMS system was also studied by changing the flow rate of the carrier gas. Using this newly designed re-circulation mode FAIMS system, the detection results of o-, p- m- xylenes in pure nitrogen and helium/nitrogen mixtures were compared. The sample and the carrier gas reserve time which ensure the success of multi-cycle detection was examined. The characteristic parameters (alpha(2), alpha(4)) and their deviation were also precisely calculated through 18 CV-DV spectra. Results show that 0.6 ng o-xylene can be detected in a 25 ml closed loop re-circulation arrangement. The effective detection time is 6.2 min in this detection process. In fact, the sample and the carrier gas used in this experiment are 70 and 826 times less than a regular open loop FAIMS system respectively. The peak position and the full width at half-maximum (FWHM) of the obtained CV-DV spectra stay almost unchanged during th.entire experiment process. The ion signal peaks can be fitted with a Gauss curve, which means that the stability of the carrier gas flow rate fully meet the requirement for on-site detection. Furthermore, the use of a helium modifier is studied and proved to be an effective method to improve the detection capacity of the FAIMS for VOCs. In conclusion, the gas-saving re-circulation design along with the gas modifiers provide new opportunities for FAIMS systems to be applied on-site high precision chemical detection. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词MASS-SPECTROMETRY ; RICH GASES ; SEPARATIONS ; SYSTEM ; CONFORMERS ; PEPTIDES ; HYDROGEN ; PROTEIN ; FLOW
WOS研究方向Physics ; Spectroscopy
语种英语
WOS记录号WOS:000397692200002
资助机构National Natural Science Foundation of China(61374016) ; National Natural Science Foundation of China(61374016) ; National Natural Science Foundation of China(61374016) ; National Natural Science Foundation of China(61374016) ; Youth Innovation Promotion Association, CAS(2013213) ; Youth Innovation Promotion Association, CAS(2013213) ; Youth Innovation Promotion Association, CAS(2013213) ; Youth Innovation Promotion Association, CAS(2013213) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083) ; National Natural Science Foundation of China(61374016) ; National Natural Science Foundation of China(61374016) ; National Natural Science Foundation of China(61374016) ; National Natural Science Foundation of China(61374016) ; Youth Innovation Promotion Association, CAS(2013213) ; Youth Innovation Promotion Association, CAS(2013213) ; Youth Innovation Promotion Association, CAS(2013213) ; Youth Innovation Promotion Association, CAS(2013213) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083) ; Science and Technology Service program of Chinese Academy of Sciences(KFJ-EW-STS-083)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/32904]  
专题合肥物质科学研究院_中科院合肥智能机械研究所
作者单位1.Chinese Acad Sci, Hefei Inst Intelligent Machines, State Key Lab Transducer Technol, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Dept Precis Machinery & Precis Instrumentat, Hefei 230026, Peoples R China
3.Dalhousie Univ, Dept Elect & Comp Engn, Halifax, NS B3J 1Z1, Canada
4.Zhejiang Univ, Dept Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Ruan, Zhiming,Chen, Chilai,Chen, Ran,et al. Gas modifier assisted re-circulation mode high-field asymmetric waveform ion mobility spectrometry (FAIMS)[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,2017,414(无):8-12.
APA Ruan, Zhiming.,Chen, Chilai.,Chen, Ran.,Liu, Youjiang.,Wang, Xiaozhi.,...&Yu, Jianwen.(2017).Gas modifier assisted re-circulation mode high-field asymmetric waveform ion mobility spectrometry (FAIMS).INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,414(无),8-12.
MLA Ruan, Zhiming,et al."Gas modifier assisted re-circulation mode high-field asymmetric waveform ion mobility spectrometry (FAIMS)".INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 414.无(2017):8-12.

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来源：合肥物质科学研究院

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