Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model
文献类型：期刊论文
| 作者 | Tang H; Jia WS; Hou XL ; Zhao YN; Huan Y(郇勇); Chen W; Yu W; Zhu MMO; Ye G; Chen B
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| 刊名 | BIOMEDICAL MATERIALS
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 13期号:3页码:31001 |
| 关键词 | collagen basic fibroblast growth factor collagen-binding domain corpus spongiosum urethral regeneration |
| ISSN号 | 1748-6041 |
| DOI | 10.1088/1748-605X/aa9f01 |
| 英文摘要 | Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration in vivo. In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF. The results demonstrate that CBD-bFGF promotes corpus spongiosum regeneration resulting in improved outcomes following urethral reconstruction. Modifying collagen biomaterials with CBD-bFGF may represent an effective strategy for urethral substitution in urethral reconstruction. |
| 分类号 | 二类 |
| URL标识 | 查看原文 |
| WOS关键词 | FIBROBLAST-GROWTH-FACTOR ; URETHRAL RECONSTRUCTION ; STEM-CELLS ; RABBIT MODEL ; BINDING BFGF ; DEFECTS ; INJURY ; RATS ; URETHROPLASTY ; IMPROVES |
| WOS研究方向 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000425739900001 |
| 资助机构 | National Key R&D Program of China [2016YFC1000807, 2016YFC1000800, 2016YFC1000801, 2016YFC1000802] |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/77924]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 作者单位 | 1.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Dept Chem Def Med, Chongqing 400038, Peoples R China 2.Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Urol,Ctr Nephrol, Chongqing 400037, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China 5.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Cadet 17 Battal, Chongqing 400038, Peoples R China 6.Third Mil Med Univ, Army Med Univ, Coll Prevent Med,Chongqing Engn Res Ctr Nanomed, Inst Combined Injury,State Key Lab Trauma Burns &, Chongqing 400038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang H,Jia WS,Hou XL,et al. Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model[J]. BIOMEDICAL MATERIALS,2018,13(3):31001. |
| APA | Tang H.,Jia WS.,Hou XL.,Zhao YN.,Huan Y.,...&Dai JW.(2018).Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model.BIOMEDICAL MATERIALS,13(3),31001. |
| MLA | Tang H,et al."Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model".BIOMEDICAL MATERIALS 13.3(2018):31001. |
入库方式： OAI收割
来源：力学研究所
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